1YTY,2VOD,1S79,1ZH5,5ZOM


Conserved Protein Domain Family
RRM1_La

?
cd12291: RRM1_La 
Click on image for an interactive view with Cn3D
RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
This subfamily corresponds to the RRM1 of La autoantigen, also termed Lupus La protein, or La ribonucleoprotein, or Sjoegren syndrome type B antigen (SS-B), a highly abundant nuclear phosphoprotein and well conserved in eukaryotes. It specifically binds the 3'-terminal UUU-OH motif of nascent RNA polymerase III transcripts and protects them from exonucleolytic degradation by 3' exonucleases. In addition, La can directly facilitate the translation and/or metabolism of many UUU-3' OH-lacking cellular and viral mRNAs, through binding internal RNA sequences within the untranslated regions of target mRNAs. La contains an N-terminal La motif (LAM), followed by two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). It also possesses a short basic motif (SBM) and a nuclear localization signal (NLS) at the C-terminus.
Statistics
?
PSSM-Id: 409733
Aligned: 43 rows
Threshold Bit Score: 57.601
Created: 10-Feb-2012
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1YTY; Homo sapiens La autoantigen binds UUUOH 3'-terminii of nascent RNA pol III transcripts, contacts at 4A.
    View structure with Cn3D
  • Structure:2VOD; Homo sapiens La protein in complex with RNA oligomer AUAUUUU, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #                ###              # #                   
1YTY_A           112 SVYIKGFPTDa------------TLDDIKEWLed--kGQVLNIQXRRtlh-kaFKGSIFVVFDSiESAKKFVEtp----- 171 human
P33399           124 TLAVMNFPHEdveas----qipeLQENLEAFFkk--lGEINQVRLRRdhrnkkFNGTVLVEFKTiPECEAFLKsysndde 197 Saccharomyc...
CCH58609         104 SLVVSGFKHEdvtke----nfneTFDKISGFLqglkdVEINQLRLQKgkhqqrFNGVVFVEFPSeEDSKKFLEdyggeep 179 Tetrapisisp...
EAA33272         177 SVYVKGFGEEtg----------sTQFDIEAFFtk--fGQVNLVKLRRnee-nkFKGSVFVEFKTeDEANAFVAlnp---- 239 Neurospora ...
jgi:MICPUN_55433 127 SLYVSPFPMDv------------TIDKLREFFsh--hVEVLSIRLRRhalskdFKGSIFIELESsTSCAVLLQnsh---- 188 Micromonas ...
XP_001697144     116 SLYARPFPMDa------------TVDTITELFng--hGTVNCVRMRRhvrskmFKGSVFVEFSSvEEAEKVLAka----- 176 Chlamydomon...
ABO94238         172 FVFASPFAKDa------------TIEALLAYFkt--vGNARSIRLRRhttskdFRGSIFVEFATeEEAKAIAEra----- 232 Ostreococcu...
XP_002672025      98 TLYAKGFPLDes---------vaNLDSIKALFep--fGKVVCVRARRekn-gtFKGSAFIEFDSeSTVNELAGks----- 160 Naegleria g...
EIE26293         117 SLFASPFPYDt------------TLDAVTAFFnt--vAPVNCVRMRRhlnssdFRGSVFVEFACeEQATEVMSks----- 177 Coccomyxa s...
EIE86592          98 SVHVKGFPLVdvdaekpadklieLQDKIDDFFne--kAKVLCTRLKKdg--rkFKGTAYVEFENpEQAKKIAElk----- 168 Rhizopus or...
Feature 1                           
1YTY_A           172 ---gqKYKETDLLIL 183 human
P33399           198 sneilSYEGKKLSVL 212 Saccharomyces cerevisiae S288c
CCH58609         180 reeklAFEGVPLEIV 194 Tetrapisispora blattae CBS 6284
EAA33272         240 ---apKWQDQELVIK 251 Neurospora crassa OR74A
jgi:MICPUN_55433 189 ---alEYEGANLTVM 200 Micromonas sp. RCC299
XP_001697144     177 ----vEFAGATLRLQ 187 Chlamydomonas reinhardtii
ABO94238         233 ---dlEYKGAKLTLM 244 Ostreococcus lucimarinus CCE9901
XP_002672025     161 ---dfKFGESVLLLE 172 Naegleria gruberi strain NEG-M
EIE26293         178 ----lVYEGAPLRLE 188 Coccomyxa sp. C-169
EIE86592         169 ---evDFDGHTLTIL 180 Rhizopus oryzae RA 99-880

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap