Conserved Protein Domain Family

cd12290: RRM1_LARP7 
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RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
This subfamily corresponds to the RRM1 of LARP7, also termed La ribonucleoprotein domain family member 7, or P-TEFb-interaction protein for 7SK stability (PIP7S), an oligopyrimidine-binding protein that binds to the highly conserved 3'-terminal U-rich stretch (3' -UUU-OH) of 7SK RNA. LARP7 is a stable component of the 7SK small nuclear ribonucleoprotein (7SK snRNP). It intimately associates with all the nuclear 7SK and is required for 7SK stability. LARP7 also acts as a negative transcriptional regulator of cellular and viral polymerase II genes, acting by means of the 7SK snRNP system. It plays an essential role in the inhibition of positive transcription elongation factor b (P-TEFb)-dependent transcription, which has been linked to the global control of cell growth and tumorigenesis. LARP7 contains a La motif (LAM) and an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), at the N-terminal region, which mediates binding to the U-rich 3' terminus of 7SK RNA. LARP7 also carries another putative RRM domain at its C-terminus.
PSSM-Id: 409732
Aligned: 16 rows
Threshold Bit Score: 93.5469
Created: 13-Sep-2011
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
XP_002613707 123 TVYVECLPrtvtHEWIKTTFSVCGKVAYISLPRFKtsgdtKGFAFIEFEKqEEAEKACKmlnnppd-----hmvgkmGVF 197 Florida lancelet
XP_002110433 126 TIYVEVIPkrvdHEWVRKHFDKFGEILYVSIPKYKstgdnKGFAFVEYKDpENAQKACRayienstfn-dselennsGQE 204 Trichoplax adha...
AEO34412      84 TLYVERLPphadHAWLKGVFSRHGQVVYVSLPRYRhnnriKGFAFIEFATaEDVDRACQhfgy----------hdgnSKK 153 Amblyomma macul...
EFX64977      84 TVYVERLPphasIEWITSIFSEYGVVAYVSLPKFKdvtriKGFAFVEFCDpESAAKAVTayasssey---hlltedpGQL 160 common water flea
EGD77445     156 TIYVEKLPeafeHDDINALFSRFGTIEYISLPRWPnr-khKGFAFIEFATpLEASACRAhyahqdvpavpmaarcwkGPP 234 Salpingoeca sp....
Q9W362       148 TLYVEALPanatHDWLKEVFSRYGPVAYVSLPHYPgtkkiKEFAFIEFEKsGSLEKAVKafa------------qiqGVL 215 fruit fly
CCD78884     139 LRNITSASwe-lGDWIRNVFEEYGEVLFVSLPRYHhsnslRGFAFVEFRTsKSARKAVKhmclf---------meneQWL 208 Schistosoma man...
EFA76751     124 TIYIEPVPenmtNEELIALFSELGSIENVSIPRFPdk-raKGFAFIEFKEkENAINAITsirsnk-------ekyklRTL 195 Polysphondylium...
EGG18030     110 TIYIEPILiedtIENIKEIFKTFGEIVYTSIPRLPdr-tpKGFAFIEFTSkESANNALVgiadsh------tsqdqtKPF 182 Dictyostelium f...
4WKR_A       201 PKTVK 205 human
XP_002613707 198 PKTRK 202 Florida lancelet
XP_002110433 205 SGNVD 209 Trichoplax adhaerens
AEO34412     154 PEVVA 158 Amblyomma maculatum
EFX64977     161 CNIQA 165 common water flea
EGD77445     235 VDPAT 239 Salpingoeca sp. ATCC50818
Q9W362       216 SVETD 220 fruit fly
CCD78884     209 VQPTE 213 Schistosoma mansoni
EFA76751     196 SKIDW 200 Polysphondylium pallidum PN500
EGG18030     183 YRFRA 187 Dictyostelium fasciculatum
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