5ZOJ


Conserved Protein Domain Family
RRM_Man1

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cd12286: RRM_Man1 
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RNA recognition motif (RRM) found in inner nuclear membrane protein Man1 (Man1) and similar proteins
This subfamily corresponds to the RRM of Man1, also termed LEM domain-containing protein 3 (LEMD3), an integral protein of the inner nuclear membrane that binds to nuclear lamins and emerin, thus playing a role in nuclear organization. It is part of a protein complex essential for chromatin organization and cell division. It also functions as an important negative regulator for the transforming growth factor (TGF) beta/activin/Nodal signaling pathway by directly interacting with chromatin-associated proteins and transcriptional regulators, including the R-Smads, Smad1, Smad2, and Smad3. Moreover, Man1 is a unique type of left-right (LR) signaling regulator that acts on the inner nuclear membrane. Man1 plays a crucial role in angiogenesis. The vascular remodeling can be regulated at the inner nuclear membrane through the interaction between Man1 and Smads. Man1 contains an N-terminal LEM domain, two putative transmembrane domains, a MAN1-Src1p C-terminal (MSC) domain, and a C-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). The LEM domain interacts with the DNA and chromatin-binding protein Barrier-to-Autointegration Factor, and is also necessary for efficient localization of MAN1 in the inner nuclear membrane. Research has indicated that C-terminal nucleoplasmic region of Man1 exhibits a DNA binding winged helix domain and is responsible for both DNA- and Smad-binding.
Statistics
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PSSM-Id: 409728
Aligned: 16 rows
Threshold Bit Score: 143.637
Created: 15-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ZOJ_D        27 CLKIRNMFDPvmeigdqWHLAIQEAILEKCSd-nDGIVHIAVDKnsrEGCVYVKCLSpEYAGKAFKALHGsWFDGKLVTV 105 human
XP_001633788 212 CLKIRNMFDHevemeegWHVLIQDAILEKCSdagANIVHIAVDKssnEGCVYVKCDShDSAGIAFKSLHGcWFDGRLVAV 291 starlet sea ane...
XP_002403644 539 CLKIRNMFDLeveyecdWPVQIRNAILEKCEg-nQGIVHLQVDTaskEGCVYMKCSSlEAAGQAYRALHGsWFDGNLITV 617 black-legged tick
EFX89547     129 CLKVRNMFDAevevgdsWPVRIQDAILEKADk--GKTVHMAVDRgsrEGCVYIKCASaDDAGKVYHSLHGwWFDGNLVTV 206 common water flea
XP_002112660 125 CLKLGNMFDYelesgsdWTSRIQDAILEKCGd-sSSIVHIHVERysnRGSVYIKCSQiEDAKETFKAMHGcIFDGRIVRA 203 Trichoplax adha...
CCD77250     689 CLKIRNMFSTesi-derGRKRIKRELLKKLAp-cGPILHIGLDSvgtNGLVYIKCGDpETAGRVFHSIHAnYFDGRLLTV 766 Schistosoma man...
NP_611873    542 CLKIRHMFDSsevdqanLKQSIVESIIEKVGt-rCKICDVQLDVq--SCCVYIRCASeEDAGTIHKEINGwWFDKRLISI 618 fruit fly
CBY22115     631 CLKIRNLLAPkdq-nkdEHDLIRKTILNWCSg-lNGIYDIELVPe--DGTVYIKCSScEMAGKAYERMRAnWYKRNLIQI 706 Oikopleura dioica
EFN83277     712 CLKIRHMFDPeieteddWETKVQDAILEKCGe-sVKILHIRVDIasrEGCVYMKCLSqEDAGKAYRALHGcWFDGNLVTV 790 Harpegnathos sa...
EMP26393     109 CLKIRNMFDPvmeigdhWHLAIQEAILEKCSd-nDGIVHIAVDKnsrEGCVYVKCLSpEYAGKAFKALHGsWFDGKLVTV 187 Green sea turtle
5ZOJ_D       106 KYLrlDRYHHRFP 118 human
XP_001633788 292 KYLtlKRYHQRFP 304 starlet sea anemone
XP_002403644 618 KYLrlERYHERFP 630 black-legged tick
EFX89547     207 KYLrpERYHYRFP 219 common water flea
XP_002112660 204 RFIsnQTYHSLFP 216 Trichoplax adhaerens
CCD77250     767 KFLrdNKYCLRFP 779 Schistosoma mansoni
NP_611873    619 KFLrlERYLSRFP 631 fruit fly
CBY22115     707 KYIklSVYHRRFK 719 Oikopleura dioica
EFN83277     791 KYLrlERYHERFP 803 Harpegnathos saltator
EMP26393     188 KYLrlDRYHHRFP 200 Green sea turtle
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