2JRS,2DNZ


Conserved Protein Domain Family
RRM2_RBM23_RBM39

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cd12284: RRM2_RBM23_RBM39 
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RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein RBM23, RBM39 and similar proteins
This subfamily corresponds to the RRM2 of RBM39 (also termed HCC1), a nuclear autoantigen that contains an N-terminal arginine/serine rich (RS) motif and three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). An octapeptide sequence called the RS-ERK motif is repeated six times in the RS region of RBM39. Although the cellular function of RBM23 remains unclear, it shows high sequence homology to RBM39 and contains two RRMs. It may possibly function as a pre-mRNA splicing factor.
Statistics
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PSSM-Id: 409726
Aligned: 32 rows
Threshold Bit Score: 124.661
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2JRS_A        29 LYVGSLHFNITEDMLRGIFEPFGrIESIQLMMDsETGRSKGYGFITFSDsECAKKALEQL-NGFELAGRPMKVGHVTER 106 human
EFJ02548     184 LYVGSLHFNLTEADIKQVFEPFGeLEFVDLHRDpTTGRSKGYAFVQYKRaEDARMAMEQM-EGFELAGRQLKVNTVHDK 261 Schizophyllum co...
AAD22102     283 LYVGNIHFSITEQDLQNVFEPFGeLEFVQLQKD-DNGRSRGYGFVQFRDaGQAREALEKM-NGFDLAGRPIRVGLGNDK 359 Neurospora crassa
XP_002976923 274 LYVGNLHVNITEDQLRQVFEPFGvIELVQLPLDqETGLCKGYGFVQYSKlEDARAAQQGLnGILELAGRAIKVSAVTDQ 352 Selaginella moel...
CAG79917     448 LYVGNIYFGVTEGEIIQIFEAFGpIEFADLQKE-KTGKSKGYCFIQYVNpDDAKTALEKM-NGFELAGRKLRVGLGLGE 524 Yarrowia lipolyt...
AAM20703     146 LYVGNLHINMSEDDLRKVFESFGsVELVQVPRD-ETGLCKGFGFVQFARlEDARNALNLN-GQLEIAGRAIKVSAVTDQ 222 thale cress
O13845       342 LCVSNIHFNLTDEDVKAIFEPFGdIEFVHLQRD-DQNRSKGFGYIQYRNpISARNALEKM-NGFDLAGRNMRVCLGNDK 418 Schizosaccharomy...
EIE25597     235 LYIGNLHPNIQEQDLKQVFEAFGaVEYITLQKD-PTGRSQGYGFVQYQTtPDATKAMQQL-DGLDIAGSQISVKIAPLT 311 Coccomyxa sp. C-169
XP_005703854 308 LYVGSIHFSISEDDLRTIFEPFGeVISLQLHKDpETGRSRGFGFVQYKNhEDAKKAFEQL-NGLDLAGRPLKVGLATAE 385 Galdieria sulphu...
CCJ30702     228 LYVGNIHFNLTEDDLRQIFEPFGeLEFVQLQKEpDTGRSRGYGFVQYRDpAQARDALEKM-NGFELAGRAIRVGLGNDK 305 Pneumocystis jir...
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