2CQ4,2MHN


Conserved Protein Domain Family
RRM1_RBM39_like

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cd12283: RRM1_RBM39_like 
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RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 39 (RBM39) and similar proteins
This subfamily corresponds to the RRM1 of RNA-binding protein 39 (RBM39), RNA-binding protein 23 (RBM23) and similar proteins. RBM39 (also termed HCC1) is a nuclear autoantigen that contains an N-terminal arginine/serine rich (RS) motif and three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). An octapeptide sequence called the RS-ERK motif is repeated six times in the RS region of RBM39. Although the cellular function of RBM23 remains unclear, it shows high sequence homology to RBM39 and contains two RRMs. It may possibly function as a pre-mRNA splicing factor.
Statistics
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PSSM-Id: 409725
Aligned: 25 rows
Threshold Bit Score: 114.635
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2CQ4_A        27 TVFCMQLAariRPRDLEDFFSa---vGKVRDVRIIsdrnsrrskGIAYVEFCeiQSVPLAIGLTgqr-------llGVPI 96  human
CBQ67560     256 SVFCSQLSarlGQRDLGEFFEdhlgeGAVQDVRIVmdrvtrrskGVGYVEFAarELVPKAIELTgti-------lfGIPI 328 Sporisorium rei...
AAD22102     183 TVFVQQLAarlRTRELKEFFEk---vGPVAEAQIVkdrvsnrskGVGYVEFKneDSVQAALQLTgqk-------llGIPV 252 Neurospora crassa
XP_001349956 488 TVLVLNLDlkaDERDIYEFFSev--aGKVRDIQCIkdqrsgkskGVAYVEFYtqEAVIKALAANgmm-------lkNRPI 558 Plasmodium falc...
EFA79920     219 TVFVSKLSpkiTENDLYEFFAq---aGKVLKVSLVidkitkrlkGVGYVEFSerEMVEKAVLLTgqk-------vlNQSI 288 Polysphondylium...
XP_504318    331 TVYVQQVAphvQSTELFDFFAe---aGPVHDVSLVkdrs-srcrGVAFVEFEdvESVSRAIGLTgrs-------lhGQAL 399 Yarrowia lipoly...
CAK73355     159 TVLMYCLPlkaKEKHIYQFFQtf-ncGKIRDIRIIrdqksgrsrGVAYVEFYqeESIPMALALNdrlfimdgqqvgTIPV 237 Paramecium tetr...
O13845       241 TVFVSQLAnrlTSRELYDFFEq---aGPVRDAQIVrdkisgrskGVAYVEFCheDSVQAAIALSgkr-------llGLPV 310 Schizosaccharom...
EIE25597     127 TVFAYNLPlkaEERDLFEFFSk---aGPIEDVKIImdrntrkskGFAYIEYTnkADIVTAMALTgqi-------lmGQAV 196 Coccomyxa sp. C...
XP_026309556 379 TVLVLNLDlkaDEKDIYEFFSei--aGKVRDIQCIkdqrsgkskGVAYVEFYtqESVIKALAANghv-------fkNKPI 449 Ugandan red Col...
2CQ4_A        97 IVQ 99  human
CBQ67560     329 VVQ 331 Sporisorium reilianum SRZ2
AAD22102     253 IVQ 255 Neurospora crassa
XP_001349956 559 KIQ 561 Plasmodium falciparum 3D7
EFA79920     289 LVH 291 Polysphondylium pallidum PN500
XP_504318    400 LIR 402 Yarrowia lipolytica CLIB122
CAK73355     238 KIQ 240 Paramecium tetraurelia strain d4-2
O13845       311 IVQ 313 Schizosaccharomyces pombe 972h-
EIE25597     197 MVK 199 Coccomyxa sp. C-169
XP_026309556 450 KIQ 452 Ugandan red Colobus
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