Conserved Protein Domain Family

cd12280: RRM_FET 
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RNA recognition motif (RRM) found in the FET family of RNA-binding proteins
This subfamily corresponds to the RRM of FET (previously TET) (FUS/TLS, EWS, TAF15) family of RNA-binding proteins. This ubiquitously expressed family of similarly structured proteins predominantly localizing to the nuclear, includes FUS (also known as TLS or Pigpen or hnRNP P2), EWS (also known as EWSR1), TAF15 (also known as hTAFII68 or TAF2N or RPB56), and Drosophila Cabeza (also known as SARFH). The corresponding coding genes of these proteins are involved in deleterious genomic rearrangements with transcription factor genes in a variety of human sarcomas and acute leukemias. All FET proteins interact with each other and are therefore likely to be part of the very same protein complexes, which suggests a general bridging role for FET proteins coupling RNA transcription, processing, transport, and DNA repair. The FET proteins contain multiple copies of a degenerate hexapeptide repeat motif at the N-terminus. The C-terminal region consists of a conserved nuclear import and retention signal (C-NLS), a putative zinc-finger domain, and a conserved RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), which is flanked by 3 arginine-glycine-glycine (RGG) boxes. FUS and EWS might have similar sequence specificity; both bind preferentially to GGUG-containing RNAs. FUS has also been shown to bind strongly to human telomeric RNA and to small low-copy-number RNAs tethered to the promoter of cyclin D1. To date, nothing is known about the RNA binding specificity of TAF15.
PSSM-Id: 409722
Aligned: 9 rows
Threshold Bit Score: 125.601
Created: 13-Sep-2011
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
2LA6_A        16 IFVQGLGenVTIESVADYFKqigiikt------nkktgqPMINLYTDRetgklKGEATVSFDDPPSAKAAIDWFDgke-- 87  human
2CPE_A        18 IYVQGLNdsVTLDDLADFFKqcgvvkm------nkrtgqPMIHIYLDKetgkpKGDATVSYEDPPTAKAAVEWFDgkd-- 89  human
Q27294       122 IFVSGMDpsTTEQDIETHFGaigiikk------dkrtmkPKIWLYKNKetgasKGEATVTYDDTNAAQSAIEWFDgrd-- 193 fruit fly
AAR28021     282 IYISNLPpdVTTDELKDLFGgigqvgrikqkrgykdqwpYNIKIYTDEkg-nyKGDACLAYEDPSAAHSAGGFFNnye-- 358 thale cress
CCA23378     169 IYISNLPddVTIDELQEIFGaigivarekqkrgfkdqwpFKIKMYTDEag-kfKGDAVLTYEDANAARTAPSFFNgse-- 245 Albugo laibachi...
EFJ35242     207 IYISNLPldVQIEELRTLFGgigqvarikqrrgykdqwpWNIKLYTDDgg-nnKGDGVLCYEDPSAAHAAGGFFNgyn-- 283 Selaginella moe...
NP_495483    203 VFVQGISttANEAYIADVFStcgdia--------kndrgPRIKIYTDRntgepKGECMITFVDASAAQQAITMYNgqpfp 274 nematode
XP_002738491 269 VFVSGLLktVTEEQLAEHFGqigvikn------drrtnkPKIWMYMNKetgepKGECTITYDDASAAKAAIEWFNgkpla 342 Saccoglossus ko...
XP_019577731 202 IYISNLPpdVTIDELKDLFGgigqvgrikqkrgykdqwpYNIKIYTDEkg-knKGDACLAYEDPSAAHSAGGFFNnye-- 278 Chinese rufous ...
2LA6_A        88 fsGNPIKVSF 97  human
2CPE_A        90 fqGSKLKVSL 99  human
Q27294       194 fnGNAIKVSL 203 fruit fly
AAR28021     359 mrGNKISVTM 368 thale cress
CCA23378     246 irGKAIKVEL 255 Albugo laibachii Nc14
EFJ35242     284 lrGNEIKVSM 293 Selaginella moellendorffii
NP_495483    275 ggSSPMSISL 284 nematode
XP_002738491 343 gnGPEIKVEF 352 Saccoglossus kowalevskii
XP_019577731 279 mrGNKIGVVM 288 Chinese rufous horseshoe bat
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