2KRB,3NS6,5A5U,5K1H,2NLW,3NS5,4UER


Conserved Protein Domain Family
RRM_eIF3B

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cd12278: RRM_eIF3B 
Click on image for an interactive view with Cn3D
RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
This subfamily corresponds to the RRM domain in eukaryotic translation initiation factor 3 (eIF-3), a large multisubunit complex that plays a central role in the initiation of translation by binding to the 40 S ribosomal subunit and promoting the binding of methionyl-tRNAi and mRNA. eIF-3B, also termed eIF-3 subunit 9, or Prt1 homolog, eIF-3-eta, eIF-3 p110, or eIF-3 p116, is the major scaffolding subunit of eIF-3. It interacts with eIF-3 subunits A, G, I, and J. eIF-3B contains an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), which is involved in the interaction with eIF-3J. The interaction between eIF-3B and eIF-3J is crucial for the eIF-3 recruitment to the 40 S ribosomal subunit. eIF-3B also binds directly to domain III of the internal ribosome-entry site (IRES) element of hepatitis-C virus (HCV) RNA through its N-terminal RRM, which may play a critical role in both cap-dependent and cap-independent translation. Additional research has shown that eIF-3B may function as an oncogene in glioma cells and can be served as a potential therapeutic target for anti-glioma therapy. This family also includes the yeast homolog of eIF-3 subunit B (eIF-3B, also termed PRT1 or eIF-3 p90) that interacts with the yeast homologs of eIF-3 subunits A(TIF32), G(TIF35), I(TIF34), J(HCR1), and E(Pci8). In yeast, eIF-3B (PRT1) contains an N-terminal RRM that is directly involved in the interaction with eIF-3A (TIF32) and eIF-3J (HCR1). In contrast to its human homolog, yeast eIF-3B (PRT1) may have potential to bind its total RNA through its RRM domain.
Statistics
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PSSM-Id: 409720
Aligned: 48 rows
Threshold Bit Score: 88.0196
Created: 18-Nov-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
polypeptidedimer interface
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #  #      #  ## ### ##  #                                           #### ##
2KRB_A         1 DSVIVVDNVPqvgpDRLEKLKNVIHKIFSKf----GKITNDFYPeed----gkTKGYIFLEYASpaHAVDAVKNADGyKL 72  human
BAJ94994      38 DTFVVIDGLPivneDQKPRLIKFLLKRLNTvgrikDGEESIFMPmsd---agqSEGFAFVEYQTpeQAVAATKQLHGtAL 114 domesticated ba...
NP_594528     38 DTVVVIEGAPvveeAKQQDFFRFLSSKVLAki-gkVKENGFYMPfeekngkkmSLGLVFADFENvdGADLCVQELDGkQI 116 Schizosaccharom...
XP_002380111  23 GTLIVLDGLPvvdkAHRPTLIRFLLRKLDSpg--pTDTRKVYMPvds---qqrTIGSAIIRYLDasQAEDTITRLNGsHL 97  Aspergillus fla...
XP_002669875  35 SNVVVIDGLPiidqAKEEALKSKVVQIIEKka--eAKIVNFYIPyqa----gkSKGMAIVELSTaeQAKKVLDGIEG-FK 107 Naegleria grube...
Q7S464        41 DAFVVVDGLPevneEQKPKLVKFLLKKLNTvg--kTREDLIFMPmge---dgkSLRFAFVEYSSpaEAAAACRQLDLvPL 115 Neurospora cras...
EGD76223      19 DNFILVDGVPvapkAKLPLLATVLTKVFKEfk--pKKVTLAEDPdt-----gnGVGAAYVEFSKpqDAKQACEKMNNhKL 91  Salpingoeca sp....
A5DR43        58 DNFVVVDGAPiapeAKVPVLIKVLKKLFSTvgeivEGEEGIHMPled----gkSKGFLFIQFKTaqMADAAIQQMHGkKL 133 Pichia guillier...
P12806        36 EHFVICDGAPiapeAKAPVLKKVLTKLFSQc----GKVVDMFMPlen----gqTKGFLIIELDSaaAADKAVKQLNGkKL 107 Ogataea angusta
3NS5_A         6 DQYIVVNGAPvipsAKVPVLKKALTSLFSKa----GKVVNMEFPidea--tgkTKGFLFVECGSmnDAKKIIKSFHGkRL 79  baker's yeast
Feature 1            ##   
2KRB_A        73 DKQHTFRVN 81  human
BAJ94994     115 DKKHTLAVN 123 domesticated barley
NP_594528    117 LKNHTFVVR 125 Schizosaccharomyces pombe 972h-
XP_002380111  98 DSNHQMTLE 106 Aspergillus flavus NRRL3357
XP_002669875 108 FASFTLHSI 116 Naegleria gruberi strain NEG-M
Q7S464       116 DKKHTLRVN 124 Neurospora crassa OR74A
EGD76223      92 DKKHTFKTL 100 Salpingoeca sp. ATCC50818
A5DR43       134 DQKHRLLVN 142 Pichia guilliermondii ATCC 6260
P12806       108 DVKHRLAVN 116 Ogataea angusta
3NS5_A        80 DLKHRLFLY 88  baker's yeast

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