Conserved Protein Domain Family

cd12277: RRM3_MEI2_EAR1_like 
RNA recognition motif 3 (RRM3) found in Mei2-like proteins and terminal EAR1-like proteins
This subfamily corresponds to the RRM3 of Mei2-like proteins from plant and fungi, terminal EAR1-like proteins from plant, and other eukaryotic homologs. Mei2-like proteins represent an ancient eukaryotic RNA-binding proteins family whose corresponding Mei2-like genes appear to have arisen early in eukaryote evolution, been lost from some lineages such as Saccharomyces cerevisiae and metazoans, and diversified in the plant lineage. The plant Mei2-like genes may function in cell fate specification during development, rather than as stimulators of meiosis. In the fission yeast Schizosaccharomyces pombe, the Mei2 protein is an essential component of the switch from mitotic to meiotic growth. S. pombe Mei2 stimulates meiosis in the nucleus upon binding a specific non-coding RNA. The terminal EAR1-like protein 1 and 2 (TEL1 and TEL2) are mainly found in land plants. They may play a role in the regulation of leaf initiation. All members in this family are putative RNA-binding proteins carrying three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). In addition to the RRMs, the terminal EAR1-like proteins also contain TEL characteristic motifs that allow sequence and putative functional discrimination between them and Mei2-like proteins.
PSSM-Id: 409719
Aligned: 22 rows
Threshold Bit Score: 103.473
Created: 4-Apr-2011
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Q8W4I9       746 LMIKNIPNKy-tSKMLLSAIDEHCkg------------------tYDFLYLPIDFkn--------kCNVGYAFINLIepe 798 thale cress
EER02485     307 VILRNIPNKy-dEIMLVEQFNASGfst---------------dshIRYVYTPKDGtn--------nCNLGYAFVDLVnhd 362 Perkinsus marin...
EER14951      75 VMLRNVPNDl-gSLDLIAIINQEGfk-----------------gaYDFLFMPHERtpss---qpdiKTKGYVFINFLseg 133 Perkinsus marin...
EER06710     105 VMVHNLRPHc-nVDYVEQVFNEVGlk-----------------gaFDFLYVPLNFkt--------rEAVGFAFVNFVdqe 158 Perkinsus marin...
EER14344     406 VMVRNIPPAy-tSSRLLQEILETMlelageeelatvnaavgapfgIDFVYLPFNLkn--------rAGVSYGFVNLTtpe 476 Perkinsus marin...
XP_002781998 560 VVMRNVPVRy-tPSTLMQEIIEYGfg-----------------geFDFFYLPFDHkr--------nCNHGYCFINLSdfs 613 Perkinsus marin...
XP_001427196 119 LMLKNIPRSm-kPNDLRNILNKEFrn------------------lYDFFYLPLDNnvfqilqfkneGHLGYAFVNFInqd 179 Paramecium tetr...
XP_002773211  66 LMLRSIPYSytpRELLDELVQKIGfq-----------------geYDFFYLPVNSkl--------sCNVGYAFMNFRnpq 120 Perkinsus marin...
XP_002771293 215 VMLRNIPYSm-gQMRVLDALLSMGfq-----------------skIDFFYAPLDFss--------gNNLGYAFINLRrpe 268 Perkinsus marin...
XP_002786941 490 LLMRNVPNDl-nQEGLVDLILKICkqrg-------------krirVNFFYAPMDSgt--------rRNLGYCFVNLQesm 547 Perkinsus marin...
Q8W4I9       799 KIVPFFKAFNGKKWEkfns-------ekvaTLTYARIQG 830 thale cress
EER02485     363 EAVRFTSVYEGFRLPssks-------rkvcSANWAKMQS 394 Perkinsus marinus ATCC 50983
EER14951     134 LAHMFRKIFQGKPLTgrfl-------lkvgDVSDAKTQG 165 Perkinsus marinus ATCC 50983
EER06710     159 HAQKMIDGFNNLILDdcm----------plVVEPAKNQG 187 Perkinsus marinus ATCC 50983
EER14344     477 ALLTFYDRFDQHEWRsgtsrthnggerkpcEMSAARLQG 515 Perkinsus marinus ATCC 50983
XP_002781998 614 VMERFAAAFDGFEENlrh---------ylgNEAFRNLDE 643 Perkinsus marinus ATCC 50983
XP_001427196 180 VVLKFYRTFNNQKWTntek--------qicQLKYAKLQG 210 Paramecium tetraurelia strain d4-2
XP_002773211 121 YCELFKEAFSHHTFEkavrg-----kkvvgQASYAHVQG 154 Perkinsus marinus ATCC 50983
XP_002771293 269 YVDEFYNKFNDVSLShlge--------awcVKRLKDLKP 299 Perkinsus marinus ATCC 50983
XP_002786941 548 MAKDFEEIFTGLELRgagr--------krvDCQWAVLQG 578 Perkinsus marinus ATCC 50983
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