Conserved Protein Domain Family
RRM_SRSF11_SREK1

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cd12259: RRM_SRSF11_SREK1 
RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11), splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
This subfamily corresponds to the RRM domain of SRSF11 (SRp54 or p54), SREK1 ( SFRS12 or SRrp86) and similar proteins, a group of proteins containing regions rich in serine-arginine dipeptides (SR protein family). These are involved in bridge-complex formation and splicing by mediating protein-protein interactions across either introns or exons. SR proteins have been identified as crucial regulators of alternative splicing. Different SR proteins display different substrate specificity, have distinct functions in alternative splicing of different pre-mRNAs, and can even negatively regulate splicing. All SR family members are characterized by the presence of one or two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and the C-terminal regions rich in serine and arginine dipeptides (SR domains). The RRM domain is responsible for RNA binding and specificity in both alternative and constitutive splicing. In contrast, SR domains are thought to be protein-protein interaction domains that are often interchangeable.
Statistics
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PSSM-Id: 409704
Aligned: 13 rows
Threshold Bit Score: 102.396
Created: 22-Sep-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q05519        34 VIQVTNVSpsASSEQMRTLFGFLGKIdELRLFPpddsp-lpvssRVCFVKFHDpdSAVVAQHLTNTVFvDRALIVVP 109 human
CBY18761     106 IVMVNNVTtkATEEQMSVLFSFIGPItEIALFPkydvs--lvqhKVCFVKFESkaDVVVALHLSNNVFiDRALQVKE 180 Oikopleura dioica
CBY19747       9 VVKIANLAitTKEDDIRHMFGYIGRMeHCQMYPrnvsl-mpvpsKVAFVKYKHkrDAAVALHLTNSILvDKCIQVIP 84  Oikopleura dioica
O01159        11 ILHVANIStsATRDHIYNMFNYLGKIqDLKVYPsegnitantllKTAFIKFDDerCVEVAQHLTNTVViDCAIVCLP 87  nematode
NP_001003613   6 VIQITNLSaaVSSDQMRTLFGFLGDIdELRLYPpdnap-lsfssKVCYIKYREpsSVGVAQHLTNTVFiDRALIVVP 81  zebrafish
NP_477347      9 VIQVTNIApqATKDQMQTLFGNIGKIeEIRLYPtirdvscpvqsRICYVKYTDttSVPVAQHLTNTVFiDRALIVIP 85  fruit fly
XP_002436264   7 VAQVTNVAptATLEQMSTLFGFLGKIlEIKMYPsdefl-lqpvaKVCYIRYEEpwSVGVAQHLTNTVFvDRALIVVP 82  black-legged tick
XP_002605978   6 VIQVTNVApaATKEQMQTLFSFLGKIdEIKLYPedisv--pvtsKVCYVKYDDptNCGVAQHLTNTVFiDRALIVVP 80  Florida lancelet
EFX89411      19 IVQVTNVApqANKEQMQTLFGIIGKIeDLRLYPtlrdlnapvqlRICFVKYSDpnDVPVALHLSNTVFiDRAVSVTL 95  common water flea
CCD74999       9 VVQVTNVSpsATSEQLRTLFGHVGVLeEVVVYPsddke--elasKVCYIRYQEpiNAEVALHLNNTVFlDRALIVLP 83  Schistosoma mansoni
EGD82539       2 FVGVAGVSslVREDQVRELLAKCGKVeELRVYRdntd----prqRTVCVNFEKeeDGMVALHLTDKFLiDRLIKVER 74  Salpingoeca sp. AT...
XP_002115088   3 VCQVTNVSpgATVEQLNTLFGFLGEIeELKLFPsetqa-aavtsKVCFVKYKDchSVQVARHLSNSVFiDRALIVIP 78  Trichoplax adhaerens
EGF79432      17 PLAALNLSkqITEELLCQFFSFIGPIvSISLQPcean----plvQESLVQFQDseDAALALHLTGTVLaDKALFITP 89  Batrachochytrium d...
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