2DIU


Conserved Protein Domain Family
RRM1_LKAP

?
cd12255: RRM1_LKAP 
Click on image for an interactive view with Cn3D
RNA recognition motif 1 (RRM1) found in Limkain-b1 (LKAP) and similar proteins
This subfamily corresponds to the RRM1 of LKAP, a novel peroxisomal autoantigen that co-localizes with a subset of cytoplasmic microbodies marked by ABCD3 (ATP-binding cassette subfamily D member 3, known previously as PMP-70) and/or PXF (peroxisomal farnesylated protein, known previously as PEX19). It associates with LIM kinase 2 (LIMK2) and may serve as a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures. LKAP contains two RNA recognition motifs (RRMs), also known as RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). However, whether those RRMs are bona fide RNA binding sites remains unclear. Moreover, there is no evidence of LAKP localization in the nucleus. Therefore, if the RRMs are functional, their interaction with RNA species would be restricted to the cytoplasm and peroxisomes.
Statistics
?
PSSM-Id: 409700
Aligned: 10 rows
Threshold Bit Score: 109.752
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2DIU_A          8 CHTLLYVYNLPa--NKDGKSVSNRLRRLSDNCGGKVLSITg-CSAILRFINQDSAERAQKRMENEDVFGNRIIVSF 80   human
AAI39490      218 SVSLLFVHRLPm--HRDAKAVANRLQRLSNNCGGKVLGVSg-GCAVLRFASAEAAERARKRMENEDVLGQRILVSH 290  zebrafish
XP_001640398  161 LSTELTILNLPv--GKDVAHIKSRLRQLSDNCGGHVISVTg-RTAAIRFANHPSAARAKKRIDGEDVFGSAIQVVY 233  starlet sea anemone
EFN83151      256 ESYDLLVSNLPd--EKDVVVIKRRLKQLSDNCGGRVVDVQs-NTAIVRFTSQSSADRAQKRMDGEYVLSSKISVRH 328  Harpegnathos salt...
EFX71022      185 DAVYLNVLNLPh--FVPPSQIRQRVQQIAGNCGGKMVQLQsgGRGIVRFNGTVAAQRALLRMEGEDVFGRKISVQF 258  common water flea
Q28FZ9        333 CQTLLYVYNLPt--NRDAKSISNRLRRLSDNCGGKVMSISg-TSAILRFANQESAERAQKRMENEDVFGNRITVSF 405  western clawed frog
Q66S24        289 CESMVVVSNLPtsqHLPKSAIRNRLSQLFENTGGRVQHVFg-KSASVSFRNQDMARRALKRLDGEDVFGNKITIRE 363  Oikopleura dioica
E1BZ85        502 CHTLLYVYNLPt--NRDSKSVSNRLRRLSDNCGGKVLSISg-SSAILRFLNQESAERAWKRMENEDVFGNRIVVSF 574  chicken
XP_014351049  327 CHTLLYVYNLPt--NRDSKSVGNRLRRLSDNCGGKVLSISg-SSAVLRFVNQENADRAQKRMENEDVFGNKISVSF 399  coelacanth
XP_007891907  508 CHTLLYVYNLPl--NRDSKQVSNRLRRLSDNCGGKVLNITg-SCAMLRFTSQESAERAQKRMEHEDVFGNKILVSF 580  elephant shark
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap