Conserved Protein Domain Family

cd12243: RRM1_MSSP 
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RNA recognition motif 1 (RRM1) found in the c-myc gene single-strand binding proteins (MSSP) family
This subfamily corresponds to the RRM1 of c-myc gene single-strand binding proteins (MSSP) family, including single-stranded DNA-binding protein MSSP-1 (also termed RBMS1 or SCR2) and MSSP-2 (also termed RBMS2 or SCR3). All MSSP family members contain two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), both of which are responsible for the specific DNA binding activity. Both, MSSP-1 and -2, have been identified as protein factors binding to a putative DNA replication origin/transcriptional enhancer sequence present upstream from the human c-myc gene in both single- and double-stranded forms. Thus, they have been implied in regulating DNA replication, transcription, apoptosis induction, and cell-cycle movement, via the interaction with c-MYC, the product of protooncogene c-myc. Moreover, the family includes a new member termed RNA-binding motif, single-stranded-interacting protein 3 (RBMS3), which is not a transcriptional regulator. RBMS3 binds with high affinity to A/U-rich stretches of RNA, and to A/T-rich DNA sequences, and functions as a regulator of cytoplasmic activity. In addition, a putative meiosis-specific RNA-binding protein termed sporulation-specific protein 5 (SPO5, or meiotic RNA-binding protein 1, or meiotically up-regulated gene 12 protein), encoded by Schizosaccharomyces pombe Spo5/Mug12 gene, is also included in this family. SPO5 is a novel meiosis I regulator that may function in the vicinity of the Mei2 dot.
PSSM-Id: 409689
Aligned: 15 rows
Threshold Bit Score: 114.328
Created: 13-Sep-2011
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1X4E_A         6 SGLYIRGLqpgtTDQDLVKLCqpy---------gkIVSTKAILDkttn----kckGYGFVDFDspsAAQKAVTALkasGV 72  human
P29558        62 TNLYIRGLpphtTDQDLVKLCqpy---------gkIVSTKAILDkttn----kckGYGFVDFDspaAAQKAVSALkasGV 128 human
Q2L4W6       296 RNVYIRGLppntSDENLLLYTnrf---------gkVSSSKAIIDmetn----lckGYGFACFEeekSALICISAMtlcGY 362 fission yeast
Q6XE24        61 TNLYIRGLppgtTDQDLIKLCqpy---------gkIVSTKAILDkntn----qckGYGFVDFDspaAAQKAVASLkanGV 127 White-cheeked G...
EFX85883       6 TNLYIRGLtpntTDKDLEELCrkf---------gtIISTKAILDkntn----kckGYGFVDFDspsAAESAVKALqlqGI 72  common water flea
EGF99019     116 PNVYIRPLppsfTDGDLEKLCtsatlklssaarhkILSVKVMVEegdtskigvckGYGFCLWSstqAASICIDGLrgeGY 195 Melampsora lari...
CBQ73395     230 TNVYVNGLpkemNDHMLYLLGsvc---------gvVISHKAMMDrqsg----qckGFGFLMYAsseMAKTAIEWLnshGF 296 Sporisorium rei...
EAA35208     255 RNVYIRGLhpttDDELLLRYAsrf---------gkVEQSKAIIDtstg----ackGFGFAKFAnvrDSEKCIRGFhhlGY 321 Neurospora cras...
XP_002436024  14 TNLYIKGLthttTDKDLLNLCapy---------gnIISTKAILDkdtn----kckGYGFVDFEsplAAEKAVKALqaqGV 80  black-legged tick
XP_001641651  15 TNLYIRGLkantTDDDLVRLChky---------gtIISTKAILDkdtn----lckGYGFVDFEspiSAQKAVAALvnkGI 81  starlet sea ane...
1X4E_A        73 QAQM 76  human
P29558       129 QAQM 132 human
Q2L4W6       363 QCSF 366 fission yeast
Q6XE24       128 QAQM 131 White-cheeked Gibbon
EFX85883      73 QAQM 76  common water flea
EGF99019     196 QASF 199 Melampsora larici-populina 98AG31
CBQ73395     297 AASF 300 Sporisorium reilianum SRZ2
EAA35208     322 EVGF 325 Neurospora crassa OR74A
XP_002436024  81 QAQM 84  black-legged tick
XP_001641651  82 QAQM 85  starlet sea anemone
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