2LPB


Conserved Protein Domain Family
gal11_coact
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cd12191: gal11_coact 
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gall11 coactivator domain
Gall11/MED15 acts in the general regulation of GAL structural genes and is required for full expression for several genes in this pathway, including GALs 1,7, and 10 in Saccharomyces cerevisiae. GAL11 function is dependent on GCN4 functionality and binds GCN4 in a degenerate manner with multiple orientations found at the GCN4-Gal11 interface.
Links
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Statistics
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PSSM-Id: 213398
Aligned: 31 rows
Threshold Bit Score: 60.8378
Created: 6-Sep-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimer
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:2LPB: Saccharomyces cerevisiae Gal11 binds GCN4, contacts at 4A
  • Comment:GCN4: Gal11 interface can occur in multiple orientations
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      ####   ##                                                             ##  #  ## 
2LPB_A       1 QRRQLTPQQQq--------------------------lVNQMKVAPIPKQLLQRIPNI------PPNINTWQQVTALAQQ 48   Saccharomyces ce...
EFQ27026   594 MPQQAQPGAPnnqqqviaqqqqmlarlrnqgtpvapahQVMMDSMDLPPPVLAQLGNQlh---aPPEVRKWKDLRQWLAQ 670  Glomerella grami...
EFY98930   568 INQPQQPQQQmqmprip---------------iqnnqaQAMMDAMDLPPHVQNIVGQL------PIEVKKWRDLKIWLSQ 626  Metarhizium anis...
EGO53710   644 QPQLNGPQNAqtatmaa--------------latnpraIQMADNLDIPADTLNALRGIlqpailPPNLKKWVHLKAWHQA 709  Neurospora tetra...
EGR48723   592 PGNQQQPMTQarmpa------------------tnpqvAYVMDSMDLPPNVLNQIQGL------PVEVKKWRDLKAWIAS 647  Trichoderma rees...
EGU84348   573 SVNMQQPQNGvpmngnpqqm--------qmprlapnqqLAMMDSMELPPQVLTQLQAQl-----PPEVKKWGQLKIWLQQ 639  Fusarium oxyspor...
EGX94538   566 MQPQQQPNTAgpnggpaqvp--------gathganpqmQTVMDNMDVPPQVRQTILVNl-----PPEVKKWRDLKMWVNS 632  Cordyceps milita...
EGY19323   386 RVRQNQPITPq--------------------------qQNAMDGMDVPPQVLMGFTNQfr---lNPEVRKWRELKAWMAQ 436  Verticillium dah...
EHK15591   569 VGNQQQPMQMgrmapp-----------------qgpqlALLMDSMDLPPNVVNQLPGL------PVEVKKWRDLKAWITQ 625  Trichoderma vire...
EHK41406   578 NQQQSMPMNRmpaq--------------------naqlHFLMDSMDLPTTILTQIQGL------PAEVKKWRDLKAWINQ 631  Trichoderma atro...

Feature 1        #      #  ##  ##  #              
2LPB_A      49 KLLTPq--dMEAAKEVYKIHQQLLfKARLQQQQAQ 81   Saccharomyces cerevisiae S288c
EFQ27026   671 NPVQPq--lQQHLERIQRSQFATYmQRQMEKRNRE 703  Glomerella graminicola M1.001
EFY98930   627 NSTLPpt-tRNQLGALQQRQFQILmQRRASMQQQA 660  Metarhizium anisopliae ARSEF 23
EGO53710   710 AGLPPh--vQDKVAQVLTTHQQQQiRQLLLQKQQR 742  Neurospora tetrasperma FGSC 2508
EGR48723   648 NGGNLqpnmRSQLAAIQQRQFQIAmSRRNGNVPQQ 682  Trichoderma reesei QM6a
EGU84348   640 NNIPQq--lRTQLAAVQQRQFQLAlQRRASIIQQQ 672  Fusarium oxysporum Fo5176
EGX94538   633 TNNIApq-aKAALTHLQKSQFQHWwTNRSQLAQQQ 666  Cordyceps militaris CM01
EGY19323   437 NQVPQq--tMEQVEKYQRQQFAGHmQKQMERRTLQ 469  Verticillium dahliae VdLs.17
EHK15591   626 NNNSIqpqnRNQLLVIQQRQFQMLmQRRAGNLPQQ 660  Trichoderma virens Gv29-8
EHK41406   632 NNTLQps-iRGQLAAFQQKQFQMLmQRRAANAPPQ 665  Trichoderma atroviride IMI 206040

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