4A2W,4WYQ,3TMI,1WP9,3TBK


Conserved Protein Domain Family
helicase_insert_domain
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cd12088: helicase_insert_domain 
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helicase_insert_domain
helicase_insert_domain; This helical domain can be found inserted in a subset of SF2-type DEAD-box related helicases, like archaeal Hef helicase, MDA5-like helicases and FancM-like helicases. The exact function of this domain is unknown, but seems to play a role in interaction with nucleotides and/or the stabilization of the nucleotide complex.
Links
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Statistics
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PSSM-Id: 277187
Aligned: 6 rows
Threshold Bit Score: 61.7166
Created: 13-Jul-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4A2W_A        477 AAIISNLMSETEALMRtiayvdtlsqnskkdfgtqnyehwi-vvtqrkcrllqledkeeesricralFIC-TEHLRKYND 554  mallard
4WYQ_A          5 LMELEEALNFINDCNIsvhs--------------------------------------------kerDST-LISKQILSD 39   human
3TMI_A        242 KYIIAQLMRDTESLAKrickdlenlsqiqnrefgtqkyeqwivtvqkacmvfqmpdkdeesrickalFLY-TSHLRKYND 320  human
NP_001107132  272 QTRYLQVLERFSSRLTqmrllnqrdlrafskyqiila----------reqfrrnppphiqgpqqqgvLEGdFALLISLYH 341  zebrafish
1WP9_A        219 RKLLREMLRDALKPLAetgllessspdipkkevlr-------------agqiineemakgnhdlrglLLY-HAMALKLHH 284  Pyrococcus fu...
3TBK_A        234 KCIISQLXKETEKLAKdvseelgklfqiqnrefgtqkyeqwivgvhkacsvfqxadkeeesrvckalFLY-TSHLRKYND 312  house mouse

4A2W_A        555 ALIISEdarIIDALSYLTEFFTNvkngpyte---leqhltakFQEKEPELIALSKDE 608  mallard
4WYQ_A         40 CRAVLVvlgPWCADKVAGMMVRElqkyikheqeelhrkfllfTDTFLRKIHALCEEH 96   human
3TMI_A        321 ALIISEharMKDALDYLKDFFSNvraagfde---ieqdltqrFEEKLQELESVSRDP 374  human
NP_001107132  342 GFELLLqmgIRSLFLFIQNIFTGpre-------------ssrVRNELQRCSLFMDLY 385  zebrafish
1WP9_A        285 AIELLEtqgLSALRAYIKKLYEEakagstk------askeifSDKRMKKAISLLVQA 335  Pyrococcus furiosus DSM 3638
3TBK_A        313 ALIISEdaqXTDALNYLKAFFHDvreaafde---tereltrrFEEKLEELEKVSRDP 366  house mouse
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