Conserved Protein Domain Family
SH3_ARHGAP12
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cd12070: SH3_ARHGAP12 
Src Homology 3 domain of Rho GTPase-activating protein 12
Rho GTPase-activating proteins (RhoGAPs or ARHGAPs) bind to Rho proteins and enhance the hydrolysis rates of bound GTP. ARHGAP12 has been shown to display GAP activity towards Rac1. It plays a role in regulating hepatocyte growth factor (HGF)-driven cell growth and invasiveness. It contains SH3, WW, Pleckstin homology (PH), and RhoGAP domains. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.
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Statistics
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PSSM-Id: 213003
Aligned: 4 rows
Threshold Bit Score: 102.36
Created: 23-Nov-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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peptide ligand
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # #  #    #                 ##              # ##      
Q9BE31        15 AYIEVEYDYEYEAKDRKIVIKQGERYILVKKTnDDWWQVKPDENSKAFYVPAQYVKEVTR 74  crab-eating macaque
NP_001119879  11 TYIEVEYDYDYKSKDRLITIKHGESYLLVKKTnDDWWQVRKDDASKPFYVPAQYVREVRR 70  zebrafish
XP_003222010  13 LYIEVEYDYDYEAKDKRIVIKQGERYILVKKTnDDWWQVKKEENSKPFYVPAQYVKEVTR 72  green anole
NP_001080790  11 VFVEVEYDYEYEYKSKKIVIKQGEKYILVKKSnEDWWQVKKDENAKPLYVPAQYVKEVAR 70  African clawed frog

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