Conserved Protein Domain Family
SH3_ARHGAP27
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cd12069: SH3_ARHGAP27 
Src Homology 3 domain of Rho GTPase-activating protein 27
Rho GTPase-activating proteins (RhoGAPs or ARHGAPs) bind to Rho proteins and enhance the hydrolysis rates of bound GTP. ARHGAP27, also called CAMGAP1, shows GAP activity towards Rac1 and Cdc42. It binds the adaptor protein CIN85 and may play a role in clathrin-mediated endocytosis. It contains SH3, WW, Pleckstin homology (PH), and RhoGAP domains. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.
Links
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Statistics
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PSSM-Id: 213002
Aligned: 5 rows
Threshold Bit Score: 117.994
Created: 26-Oct-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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peptide ligand
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # #  #     #                 ##              # ##   
Q6ZUM4         10 YVLVEHPFEYTGKDGRRVAIRPNERYRLLRRStEHWWHVRREPGGRPFYLPAQYVRE 66   human
CAG06558        3 LVLVQFDFDYRAKDGRLVSIKPNESYILVSKTnEHWWHVRRDQSSRPFYVPAQYVKE 59   spotted green pufferfish
AAI24058       11 LVLVEHAFEYSSKDGKIISIKPNERYILLKRTnEHWWQVCLDKTTTPFYIPAKYVKV 67   western clawed frog
XP_003222554   13 YVLVEYAFEYVSKDGRLISIKPNERYILLRRTnDHWWHVRKSKETRPFYIPAKYVKE 69   green anole
XP_694888      15 LVLVEFEYEYEGRDGHMVCIKPNERYILLAKTnDHWWHVCKDERAKPFYIPAKYVKE 71   zebrafish

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