Conserved Protein Domain Family
SH3_SLAP2
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cd12011: SH3_SLAP2 
Src homology 3 domain of Src-Like Adaptor Protein 2
SLAP2 plays a role in c-Cbl-dependent regulation of CSF1R, a tyrosine kinase important for myeloid cell growth and differentiation. It has been shown to interact with CSF1R, c-Cbl, LAT, CD247, and Zap70. SLAPs are adaptor proteins with limited similarity to Src family tyrosine kinases. They contain an N-terminal SH3 domain followed by an SH2 domain, and a unique C-terminal sequence. They function in regulating the signaling, ubiquitination, and trafficking of T-cell receptor (TCR) and B-cell receptor (BCR) components. The SH3 domain of SLAP forms a complex with v-Abl. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.
Links
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Statistics
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PSSM-Id: 212944
Aligned: 6 rows
Threshold Bit Score: 102.899
Created: 18-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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peptide ligand
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             # #  #   #                ##              # ##    
NP_115590     36 TAVALGSFPAGGpAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKV 90  human
XP_003211956  35 QALALCDFPSGAgATAVLRMGEQLRVLSEDGEWWLVASQVSGKECLIPSSCVAKV 89  turkey
CBN81023      28 MIISLCNYPSFGhTELTMCIGELLTIISDDGDFMMVRSTTTGRESYIPTNYTAKV 82  European seabass
NP_001079859  31 IFVALYNFPLSGqTDLSIHFGEQLNILSEDGDWLKVSSASTGQECYLPTNYVAKV 85  African clawed frog
NP_001107907  36 VLVSLYDYPSRGpGDCAIRVGERLNILSDEGEWFKVSSSATGNESYIPSNYTAKL 90  zebrafish
XP_003220527  72 VAVAVCNFPSGQ-VEPIIRMGEQLKLLSEEGEWWKVESAVTGKNCCIPSNHIAKI 125 green anole

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