CDD Conserved Protein Domain Family: SH3

cd11892: SH3_MIA2

Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein

MIA2 is expressed specifically in hepatocytes and its expression is controlled by hepatocyte nuclear factor 1 binding sites in the MIA2 promoter. It inhibits the growth and invasion of hepatocellular carcinomas (HCC) and may act as a tumor suppressor. A mutation in MIA2 in mice resulted in reduced cholesterol and triglycerides. Since MIA2 localizes to ER exit sites, it may function as an ER-to-Golgi trafficking protein that regulates lipid metabolism. MIA2 contains an N-terminal SH3-like domain, similar to MIA. It is a member of the recently identified family that also includes MIA, MIAL, and MIA3 (also called TANGO). MIA is a single domain protein that adopts a SH3 domain-like fold; it contains an additional antiparallel beta sheet and two disulfide bonds compared to classical SH3 domains. Unlike classical SH3 domains, MIA does not bind proline-rich ligands.

Feature 1 ### ##### ## ### ## Q96PC5 31 KCGDLECEALINRVSAMRDYRGPDCRYLNFTKGEEISVYVKLAgerEDLWAGSKGKEFGYFPRDAVQIEEVFI 103 human XP_421254 31 KCGDWECETAMSRVQATTDYLGPDCRYLSFKTGEEIIVYSKLSrknENLWIGSKGKDFGYFPKDAVKVEEVLI 103 chicken XP_002939715 31 KCADPHCESLMFRAQAIQDYNGPDCRYLSFKVGAEIIVYYKLSgkrEDLWQGSTGKEYGFFPMHTVTIEEIYV 103 western clawed frog XP_003445537 33 ICGDSECQRLLSRVQAIRDHRGKDCRFLSFRQGDTIFVYHKLTgkrNDLWAGSIDKEFGYFPKDTVQEEEVYT 105 Nile tilapia AAI42826 29 FCGDPECERMISRVQAQRDHVTKDCRFLNFKKGDIITVYYKLTgkrNDLWAGSTEKLFGLFPKDAIKVDQLFI 101 zebrafish

Conserved Protein Domain FamilySH3_MIA2

Conserved Protein Domain Family
SH3_MIA2