1WDX,1TG0


Conserved Protein Domain Family
SH3_Bbc1
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cd11887: SH3_Bbc1 
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Src Homology 3 domain of Bbc1 and similar domains
This subfamily is composed of Saccharomyces cerevisiae Bbc1p, also called Mti1p (Myosin tail region-interacting protein), and similar proteins. Bbc1p interacts with and regulates type I myosins in yeast, Myo3p and Myo5p, which are involved in actin cytoskeletal reorganization. It also binds and inhibits Las17, a WASp family protein that functions as an activator of the Arp2/3 complex. Bbc1p contains an N-terminal SH3 domain. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.
Links
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Statistics
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PSSM-Id: 212820
Aligned: 10 rows
Threshold Bit Score: 94.3319
Created: 28-Nov-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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peptide ligand
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                # #  #      #                 ##                 # ##   
1WDX_A          8 PFKVVAQFPYKSDy---eDDLNFEKDQEIIVTSVEdAEWYFGEYQdsngdVIEGIFPKSFVAV 67   baker's yeast
1TG0_A          7 PFKVVAQFPYKSDy---eDDLNFEKDQEIIVTSVEdAEWYFGEYQdsngdVIEGIFPKSFVAV 66   baker's yeast
O42854          5 PTRVVALYPYRSSf---sDDLEFDPGQVIDVVSNLdGDWYTGTYVdsdgnRKIGSFPKDFTEP 64   Schizosaccharomyces pombe 972h-
EFY99923        4 PFRVKALYEYSSPh---eDDLNFDVGQIITVNEEEdDDWYGGEYVddhgvKKEGIFPRNFVEK 63   Metarhizium anisopliae ARSEF 23
XP_002173414    5 AHLVRASFAYQSEh---pDDLCFTEGQLINVVDEVdEDWLYGQYDmn-gtTWTGIFPRNFVEE 63   Schizosaccharomyces japonicus ...
NP_986972      10 PFDVIAKYTYESIh---dGDLNFEDGQRIEVISIEdNQWYYGHFVdgagnEQEGIFPKNYVEV 69   Ashbya gossypii ATCC 10895
EFW95484        4 PYTVIAKYPYTPSaenasDDLAFNAGQLITVTEEVdADWLFGTTKtg-geLVSGYFPRNFVER 65   Pichia angusta DL-1
EGP88120        4 LFKVKARYDFEAKe---eDDLGFPVGQIIDVTEEVdDSWLEGKYTdpsgaTQAGIFPREFVEK 63   Mycosphaerella graminicola IPO323
EGX51633        6 PYTVSALYDYNSPh---eDDLNFTTGQKIKVTEEEgTDWLHGQYRdnqgtLHQGIFPKNYVER 65   Arthrobotrys oligospora ATCC 2...
CCA39303        7 PFKVKALYQYSTDy---eEDLNFDVGQLITVSEIEdEEWFSGYYDed-gvRKEGIFPKTFVAV 65   Pichia pastoris CBS 7435

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