Conserved Protein Domain Family
SH3_BOI
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cd11886: SH3_BOI 
Src Homology 3 domain of fungal BOI-like proteins
This subfamily includes the Saccharomyces cerevisiae proteins BOI1 and BOI2, and similar proteins. They contain an N-terminal SH3 domain, a Sterile alpha motif (SAM), and a Pleckstrin homology (PH) domain at the C-terminus. BOI1 and BOI2 interact with the SH3 domain of Bem1p, a protein involved in bud formation. They promote polarized cell growth and participates in the NoCut signaling pathway, which is involved in the control of cytokinesis. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.
Links
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Statistics
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PSSM-Id: 212819
Aligned: 10 rows
Threshold Bit Score: 102.025
Created: 28-Nov-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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peptide ligand
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # #  #   #                    ##              # ##
584850         17 LYIAVNQYSKRMEDELNMKPGDKIKVITDDGEYNDGWYYGRNLRTKEEGLYPAVF 71   baker's yeast
EFW95857       10 YYSVIKEFNARLGDELTIRPGDTIELISDDSEFGDGWYMGRNLTTNRVGLYPKAF 64   Pichia angusta DL-1
CAD21496       14 ILVVIHDFQARSSDELSLTKGDRVELIERDDEFGDGWFLGKHLANGNSGLFPEVY 68   Neurospora crassa
EGX44344        9 YLRVLHDFDARSPDELTLKKNSKIELLERDEEYNDGWYLGRDPESGKVGLFPQGV 63   Arthrobotrys oligospora ATCC 24927
XP_502539      16 VLIAIHDFNNRSEDELTFVSGEQIQVIENDFEFKDGWYIGKRLITGATGLFPRVF 70   Yarrowia lipolytica CLIB122
CCC70318       26 LVEVRTAYAKRMQDELDLKVGDVIKILKDDELYHDGWYFGQNLKSMKHGLFPVVF 80   Naumovozyma castellii CBS 4309
EEQ43248        6 TYICIKQFNARLGDELSLKIGDKIQVLADDREYNDGWYMGKNLLTGEAGLYPKTF 60   Candida albicans WO-1
XP_002562224   12 ILEVLHEFGGRGEDELIMLPRDKIELIELDEGFGDAWYYGKNLRTGQTGLFPANF 66   Penicillium chrysogenum Wisconsin 54-1255
EGD98198       16 VLLVNHDFDARGADELTLRRGDKVELLELDEGFGDGWYLGRHVTENRTGLFPGVY 70   Trichophyton tonsurans CBS 112818
P39969         47 MYIAINEYFKRMEDELDMKPGDKIKVITDDEEYKDGWYFGRNLRTNEEGLYPVVF 101  Saccharomyces cerevisiae S288c

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