3PVL


Conserved Protein Domain Family
SH3_MYO7A
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cd11881: SH3_MYO7A 
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Src Homology 3 domain of Myosin VIIa and similar proteins
Myo7A is an uncoventional myosin that is involved in organelle transport. It is required for sensory function in both Drosophila and mammals. Mutations in the Myo7A gene cause both syndromic deaf-blindness [Usher syndrome I (USH1)] and nonsyndromic (DFNB2 and DFNA11) deafness in humans. It contains an N-terminal motor domain, light chain-binding IQ motifs, a coiled-coil region for heavy chain dimerization, and a tail consisting of a pair of MyTH4-FERM tandems separated by a SH3 domain. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.
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Statistics
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PSSM-Id: 212814
Aligned: 5 rows
Threshold Bit Score: 131.095
Created: 21-Nov-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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peptide ligand
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                # #  #      #                       ##              # ##   
3PVL_A        573 SKYVVALQDNPNPAgeeSGFLSFAKGDLIILDHDt-GEQVMNSGWANGINERTKQRGDFPTDCVYV 637  house mouse
9297020      1605 SKYVVALQDNPNPAgeeSGFLSFAKGDLIILDHDt-GEQVMNSGWANGINERTKQRGDFPTDCVYV 1669 human
Q9V3Z6       1560 SKYVIALQDYRAPSd-gTSFLSFFKGDLIILEDEscGESVLNNGWCIGRCDRSQERGDFPAETVYV 1624 fruit fly
EGD80527     1591 SKFCVAMTDYSSPGd-gSSFLSLTKGDLIVLDQDd-GSSVLHSGWCFGRNDRTGEEGDFPANCVYV 1654 Salpingoeca sp. ATCC50818
XP_001198040  183 SRYVVALQDCPKHSq-gSSYLSFQRGDLIVLEQEn-GDQGMNQGWCYGQNDRTGQKGDFPSDCVYV 246  purple urchin

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