2X3W


Conserved Protein Domain Family
SH3_PACSIN
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cd11843: SH3_PACSIN 
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Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
PACSINs, also called Synaptic dynamin-associated proteins (Syndapins), act as regulators of cytoskeletal and membrane dynamics. They bind both dynamin and Wiskott-Aldrich syndrome protein (WASP), and may provide direct links between the actin cytoskeletal machinery through WASP and dynamin-dependent endocytosis. Vetebrates harbor three isoforms with distinct expression patterns and specific functions. PACSINs contain an N-terminal F-BAR domain and a C-terminal SH3 domain. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.
Links
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Statistics
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PSSM-Id: 212777
Aligned: 10 rows
Threshold Bit Score: 97.8754
Created: 31-May-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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peptide ligand
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             # #  #   #                  ##             # ##  
2X3W_D         5 RVRALYDYDGQEqDELSFKAGDELTKLGEeDEQGWCRGRLDsGQLGLYPANYVE 58  house mouse
NP_001091172 347 RVRAVYDYSGQEsDELSFKAGDDLTKIEDeDEQGWCKGVTDkGQVGLYPANYVE 400 African clawed frog
EAW67961     368 RVRALYDYAGQEaDELSFRAGEELLKMSEeDEQGWCQGQLQsGRIGLYPANYVE 421 human
NP_788697    440 PVKALYDYEGAEsDELTFKQGDVFEKLEDeDEQGWCKGRMN-GRVGLYPANYVE 492 fruit fly
XP_002435449 383 PVRALYDYEGAEaDELSFKQGDQFEKLEDeDEQGWCKGRKD-GRVGLYPANYVE 435 black-legged tick
XP_002115575 386 PVRALYEYTRREsDELSFAAGDIIMKLSEeDGQGWIKGSLN-GTVGLVPANYVE 438 Trichoplax adhaerens
CBY30628     423 FFRALYDYTAHEtDEISFQAGDTLWKLTNeDEQGWCQGRLTdGSKGLYPANYVE 476 Oikopleura dioica
XP_002601055 387 PVRALYDYEGQEdDELTFKAGDLLTKLEDeDEQGWCKGKFR-GRVGLYPANYVE 439 Florida lancelet
XP_001634752 385 PVLALYDYEAAEdDELSFKAGEIVTKLSErDDQGWCRGRIN-HRTGLFPAEYVE 437 starlet sea anemone
EFX89690     424 PVKALYDYEGAEfDELSFKKGDVFEKLEDeDEQGWCKGRKD-GRVGLYPANYVE 476 common water flea

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