2YUN


Conserved Protein Domain Family
SH3_Nostrin
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cd11823: SH3_Nostrin 
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Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer
Nostrin is expressed in endothelial and epithelial cells and is involved in the regulation, trafficking and targeting of endothelial NOS (eNOS). It facilitates the endocytosis of eNOS by coordinating the functions of dynamin and the Wiskott-Aldrich syndrome protein (WASP). Increased expression of Nostrin may be correlated to preeclampsia. Nostrin contains an N-terminal F-BAR domain and a C-terminal SH3 domain. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.
Links
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Statistics
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PSSM-Id: 212757
Aligned: 12 rows
Threshold Bit Score: 97.4133
Created: 31-May-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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peptide ligand
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # #  #            #                 ##            # ##   
2YUN_A          9 LCKALYSFQARQd---------DELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEE 61   human
Q8IVI9        442 LCKALYSFQARQd---------DELNLEKGDIVIIHEKKEGGWWFGSLNGKKGHFPAAYVEE 494  human
NP_001107076  473 RCKALYSFASERe---------DELNINEGDVLEIFEKDDTGWWFGELNGQRGLFPSTYVEE 525  zebrafish
EFA03682      861 QCKALYAYTPNLt---------DELALQPGDLLSVYRQQDDGWWLGECKGNVGIFPATYVEL 913  red flour beetle
NP_572515     621 RCKALYSYTPKLy---------DELELSPGDIIEVHAKQDDGWWLGALRNHIGIFPATYVEE 673  fruit fly
XP_002592013  451 QCKAQFAFTSNEk---------DEISIQPGDIINVHEKLEDGWWCGELRGHSGYFPASYVEE 503  Florida lancelet
EFX68361      499 KCRALYSYAANMy---------DELSIQPGDVINIHDKQADGWWLGELSGTVGIFPATYVEE 551  common water flea
EFZ20876     1176 QCRAIYQYSANLn---------DELSLSPGDLITVHQKQSDGWWIGECRGRTGIFPATYVQV 1228 red fire ant
XP_003216095  454 TCTALYDYCTERe---------DELCLNKGDVIVIHHKEEDGWWYGSVKGKRGIFPATYVEE 506  green anole
XP_002936800  388 SDTTDYPNKPPRglsrrvkdlhEENTPNNGDLLEIHHKDDDGWWYGSLNGKKGYFPSTYVQE 449  western clawed frog
XP_002120023  513 RCVAIYDYAATRp---------DELSIKEGDVINVFEKGEDDWWRGEVNNQSGLFPANYVDV 565  Ciona intestinalis
XP_003383734  478 RCEAQYDYEGQQa---------DELSIQPGDIIYVTEKIDDDWWQGNLNGTVGIFPANYVDV 530  Amphimedon queenslandica

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