Conserved Protein Domain Family
SH3_SH3RF_C
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cd11785: SH3_SH3RF_C 
C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
SH3RF1 (or POSH) and SH3RF3 (or POSH2) are scaffold proteins that function as E3 ubiquitin-protein ligases. They contain an N-terminal RING finger domain and four SH3 domains. This model represents the fourth SH3 domain, located at the C-terminus of SH3RF1 and SH3RF3, and similar domains. SH3RF1 plays a role in calcium homeostasis through the control of the ubiquitin domain protein Herp. It may also have a role in regulating death receptor mediated and JNK mediated apoptosis. SH3RF3 interacts with p21-activated kinase 2 (PAK2) and GTP-loaded Rac1. It may play a role in regulating JNK mediated apoptosis in certain conditions. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.
Links
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Statistics
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PSSM-Id: 212719
Aligned: 11 rows
Threshold Bit Score: 111.019
Created: 31-May-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
peptide ligand
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # #  #   #                 ##              # ##   
Q6NRD3        771 RYRVMVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVEN 825  African clawed frog
A5D8S5        812 RYRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGRTGLFPGSFVDS 866  zebrafish
XP_002611581  960 RFRAVVPYPPQGDAELELKVGDIVYVHKKREDGWFKGTLQRTGKTGLFPGSFVES 1014 Florida lancelet
XP_420402     817 RYRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVEN 871  chicken
XP_002416605  832 RFRCIVPYPPNSEYELELKQGDVVYVHKKREDGWFKGTLQRTGKTGLFPGSFVQG 886  black-legged tick
XP_793907     902 RYRVIVPYPPTTDAELELKIGDSVFVHKKRDDGWFKGTLLRTGKTGLFPGSFAEP 956  purple urchin
AAF37265      782 RFRCIVPYPPNSDIELELHLGDIIYVQRKQKNGWYKGTHARTHKTGLFPASFVEP 836  fruit fly
XP_001636469    1 RYRVIMPYPPQSEAELELRVGDIVFVSKKRQDGWYKGTLERNGKTGLFPGVFSEK 55   starlet sea anemone
EFX81681      686 RFRCITPYPPNSEYELELRIGDIVYVHKKRDDGWYKGTLHRTGKTGLFPASFVES 740  common water flea
Q8TEJ3        827 RYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVES 881  human
CAG09232      632 RYRVVVPYPPQSEAEIELREGDVVFVHKKREDGWFKGTLQRTGETGLFPSSFVES 686  spotted green pufferfish

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