2A28


Conserved Protein Domain Family
SH3_Bzz1_2
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cd11778: SH3_Bzz1_2 
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Second Src Homology 3 domain of Bzz1 and similar domains
Bzz1 (or Bzz1p) is a WASP/Las17-interacting protein involved in endocytosis and trafficking to the vacuole. It physically interacts with type I myosins and functions in the early steps of endocytosis. Together with other proteins, it induces membrane scission in yeast. Bzz1 contains an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), a central coiled-coil, and two C-terminal SH3 domains. This model represents the second C-terminal SH3 domain. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.
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Statistics
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PSSM-Id: 212712
Aligned: 6 rows
Threshold Bit Score: 93.7169
Created: 1-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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peptide ligand
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             # #  #   #                   ##            # ##
2A28_A         2 AMEAIYAYEAQgdDEISIDPGDIITVIRGd-dGSGWTYGECDgLKGLFPTSY 52  baker's yeast
EDK37931     535 YVEALYDYQADgdDEISIRAGDRIAVIQDdtdGSGWTEGEINgERGMFPTSY 586 Pichia guilliermondii ATCC 6260
EFW94788     549 YMEILYDYEPQgdDELGVAVGDRVAVVTEd-pGTGWTEGEIDgVKGLFPTSY 599 Pichia angusta DL-1
NP_983668    574 TVTAIYDYSAQddDEISIRAGDVIKVLRGd-tGNGWTYGEVNgSKGLFPSNY 624 Ashbya gossypii ATCC 10895
XP_002553901 570 TVKALFDYEAQgdDEISIRQGDLISVLKAd-dGSGWTYGELNgQKGLFPTNY 620 Lachancea thermotolerans CBS 6340
CCE61961     582 KVQALYDYEAQgdDEISISVGDTITVIKGd-dGSGWTFGELNgIKGLFPSSY 632 Tetrapisispora phaffii CBS 4417

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