2DL5


Conserved Protein Domain Family
SH3_FCHSD_1
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cd11761: SH3_FCHSD_1 
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First Src Homology 3 domain of FCH and double SH3 domains proteins
This group is composed of FCH and double SH3 domains protein 1 (FCHSD1) and FCHSD2. These proteins have a common domain structure consisting of an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), two SH3, and C-terminal proline-rich domains. They have only been characterized in silico and their functions remain unknown. This group also includes the insect protein, nervous wreck, which acts as a regulator of synaptic growth signaling. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.
Links
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Statistics
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PSSM-Id: 212695
Aligned: 12 rows
Threshold Bit Score: 80.1
Created: 31-May-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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peptide ligand
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                # #  #   #                   ##             # ##   
2DL5_A         13 PLTCKVVYSYKASqpDELTIEEHEVLEVIEDGDm-EDWVKARNKvGQVGYVPEKYLQF 69   human
Q86WN1        470 PCPAHVVFRYQAGreDELTITEGEWLEVIEEGDa-DEWVKARNQhGEVGFVPERYLNF 526  human
AAH68909      480 PFPCQVLYSYQSSqsDELSITQGEQLEVIEDGDv-EEWVKARNKsGQVGYVPEKYITI 536  African clawed frog
CAG00919      448 PLTCKVLYSYKASqpDELTIDEQEMLEVIEDGDm-EDWVKARNKtGQVGYVPEKYLQF 504  spotted green pufferfish
XP_002598168  564 PITCTVLYPYEGQksDELTIAEGDLVEAIDDGDi-EGWVMGRNQrGEVGYVPENYLQW 620  Florida lancelet
XP_002401898  142 SVKCFGLFSYEAAnpDELSFVEQEEMEIISEGDg-DGWIKARNYkGEEGFIPQNYVEI 198  black-legged tick
XP_002125236  141 PVTCTVTYPYQATrtDELTITVGDRIEVVEDGDl-DQWVKARDAsGRMGYIPENYLEF 197  Ciona intestinalis
XP_003383633  479 PTMCKVLYSYESQrsDELDIQTDEELDVIEWDDg-DGWCKGRNKnSQEGYFPQSYVQA 535  Amphimedon queenslandica
EFX73637      547 VIKCIAFYPYTAQnaDELSMMENEELEVLLAFSegDGWVKARNYkGEEGYVPENYLDL 604  common water flea
XP_001631062  523 LGLCVVLYSFEATteDELSITEHEELELLEIDG--EGWCKGRNKaGKVGFFPEAYVEK 578  starlet sea anemone
NP_055639     471 PLTCKVVYSYKASqpDELTIEEHEVLEVIEDGDm-EDWVKARNKvGQVGYVPEKYLQF 527  human
NP_001096157  484 PLTCKVIYSYKASqpDELTIEEHEMLEVIEDGDm-EDWVKARNKsGQVGYVPEKYLQF 540  western clawed frog

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