1I1J


Conserved Protein Domain Family
SH3_MIA_like
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cd11760: SH3_MIA_like 
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Src Homology 3 domain of Melanoma Inhibitory Activity protein and similar proteins
MIA is a single domain protein that adopts a SH3 domain-like fold; it contains an additional antiparallel beta sheet and two disulfide bonds compared to classical SH3 domains. MIA is secreted from malignant melanoma cells and it plays an important role in melanoma development and invasion. MIA is expressed by chondrocytes in normal tissues and may be important in the cartilage cell phenotype. Unlike classical SH3 domains, MIA does not bind proline-rich ligands. MIA is a member of the recently identified family that also includes MIA-like (MIAL), MIA2, and MIA3 (also called TANGO); the biological functions of this family are not yet fully understood.
Links
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Statistics
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PSSM-Id: 212694
Aligned: 5 rows
Threshold Bit Score: 125.671
Created: 29-Mar-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:putative polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Comment:based on structure superposition with other SH3 domains
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          ###  #####                      ##                  ### ##     
1I1J_A         12 LCADQECSHPISMAVALQDYMAPDCRFLTIHRGQVVYVFSKLKgr--gRLFWGGSVQgdyygdlaARLGYFPSSIVREDQ 89   human
Q9JIE3         31 LCADEECVYTISLARAQEDYNAPDCRFIDVKKGQQIYVYSKLVtengaGEFWAGSVYgdhq-demGIVGYFPSNLVKEQR 109  house mouse
NP_940953      37 LCADDECSMLMYRGEALEDFTGPDCRFVNFKKGDPVYVYYKLArg--wPEVWAGSVG--------RTFGYFPKDLIQVVH 106  human
Q96PC5         31 KCGDLECEALINRVSAMRDYRGPDCRYLNFTKGEEISVYVKLAge--rEDLWAGSKG--------KEFGYFPRDAVQIEE 100  human
XP_002732076   38 SCADADCKNPISEARALGKHHPRDARFLHFNAEDTIIIFSKNAgk--rQDLWGGEVSgk-----aGLRGYFPKNFVQELK 110  Saccoglossus ...

Feature 1            
1I1J_A         90 TLK 92   human
Q9JIE3        110 VYQ 112  house mouse
NP_940953     107 EYT 109  human
Q96PC5        101 VFI 103  human
XP_002732076  111 LYE 113  Saccoglossus kowalevskii

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