3S4Z,3S4W,3S4W


Conserved Protein Domain Family
FANC

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cd11719: FANC 
Click on image for an interactive view with Cn3D
Fanconi anemia ID complex proteins FANCI and FANCD2
The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome.
Statistics
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PSSM-Id: 212593
Aligned: 3 rows
Threshold Bit Score: 1369.23
Created: 10-May-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 65 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:3S4W; Mus musculus FANCI-FANCD2 complex, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      ####   #   #                                  #  ##  ## ##                      
3S4Z_A      41 RAVGTLLRAVLKGSpcseEDGALRRYKIYSCCIQLVESgdlqqdvaSEIIGLLMLEVHhfpgPLLVDLASDFVGAvredr 120  house mouse
3S4W_A      41 RAVGTLLRAVLKGSpcseEDGALRRYKIYSCCIQLVESgdlqqdvaSEIIGLLMLEVHhfpgPLLVDLASDFVGAvredr 120  house mouse
3S4W_B      96 FYSKSLIKLLLGID----ILQPAIIKMLFEKVPQFLFEsenr-dgiNMARLIINQLKWldriVDGKDLTAQMMQLisvap 170  house mouse
Feature 1             #  ###                                              #  ##                
3S4Z_A     121 lvNGKSLELLPIILTAlatkkevlacgkgdlngEEYKRQLIDTLCSVR-WPQRYMIQLTSVFKDVcltpEEMNLVVAKVL 199  house mouse
3S4W_A     121 lvNGKSLELLPIILTAlatkkevlacgkgdlngEEYKRQLIDTLCSVR-WPQRYMIQLTSVFKDVcltpEEMNLVVAKVL 199  house mouse
3S4W_B     171 vnLQHDFITSLPEILG-----------------DSQHANVGKELGELLvQNTSLTVPILDVFSSLrldpNFLSKIRQLVM 233  house mouse
Feature 1                     #   #     #                                                      
3S4Z_A     200 TMFSKlnLQEIPPLVYQLLVLsskGSRRSVLDGIIAFFRELDKQhreeqssdel----------selitapadELYHVEG 269  house mouse
3S4W_A     200 TMFSKlnLQEIPPLVYQLLVLsskGSRRSVLDGIIAFFRELDKQhreeqssdel----------selitapadELYHVEG 269  house mouse
3S4W_B     234 GKLSSvrLEDFPVIVKFLLHS---VTDTTSLEVIAELRENLNVQqfilpsriqasqsklkskglasssgnqenSDKDCIV 310  house mouse
Feature 1         #   ## #                                                                     
3S4Z_A     270 TVILHIVFAIKldceLGRELLKHLKAGqqgdpskclcPFSIALLLSLTriqrfeeqvFDLLKTSVVKsfkdlqllqgskf 349  house mouse
3S4W_A     270 TVILHIVFAIKldceLGRELLKHLKAGqqgdpskclcPFSIALLLSLTriqrfeeqvFDLLKTSVVKsfkdlqllqgskf 349  house mouse
3S4W_B     311 LVFDVIKSAIRye-kTISEAWFKAIERiesa--aehkSLDVVMLLIIYststqtkkgVEKLLRNKIQsdc---------- 377  house mouse
Feature 1                                #       #  #                                          
3S4Z_A     350 lqtlvpqrtcvsTMILEVVRNSVHsWDHVTQGLIEFGFILMDsygpkkildgkaveigtslskmtNQHACKLGANILLET 429  house mouse
3S4W_A     350 lqtlvpqrtcvsTMILEVVRNSVHsWDHVTQGLIEFGFILMDsygpkkildgkaveigtslskmtNQHACKLGANILLET 429  house mouse
3S4W_B     378 ---------iqeQLLDSAFSTHYLvLKDICPSILLLAQTLFHs---------------------qDQRIILFGSLLYKYA 427  house mouse
Feature 1            #  ##  #   #  #                              #  #  ##  #                  
3S4Z_A     430 FK-IHEMIRQEILEQVLNRVVtrtssPINHFLDLFSDIIMYAPLi-LQNCSKVTETFDYLTFLpLQTVQGLLKAVQPLLK 507  house mouse
3S4W_A     430 FK-IHEMIRQEILEQVLNRVVtrtssPINHFLDLFSDIIMYAPLi-LQNCSKVTETFDYLTFLpLQTVQGLLKAVQPLLK 507  house mouse
3S4W_B     428 FKfFDTYCQQEVVGALVTHVCsgteaEVDTALDVLLELIVLNASamRLNAAFVKGILDYLENMsPQQIRKIFCILSTLAF 507  house mouse
Feature 1                     #  ##  # #                                                    ###
3S4Z_A     508 IS-----MSMRDSLILVLRKAMFASQLDARKSAVAGFLLLLKNFKvlgslpssqctqsigvtqvrvdvhsrysavANETF 582  house mouse
3S4W_A     508 IS-----MSMRDSLILVLRKAMFASQLDARKSAVAGFLLLLKNFKvlgslpssqctqsigvtqvrvdvhsrysavANETF 582  house mouse
3S4W_B     508 SQqpgtsNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAedrsvpsns------------sqrsanvssEQRTQ 575  house mouse
Feature 1       ##  ## ###  #                         #  ####  #  #                            
3S4Z_A     583 CLEIIDSLKRSLgQQADIRLMLYD-------GFYDVLRRNsqLASSIMQTLFSQLKQFyepepdllpplkl--------- 646  house mouse
3S4W_A     583 CLEIIDSLKRSLgQQADIRLMLYD-------GFYDVLRRNsqLASSIMQTLFSQLKQFyepepdllpplkl--------- 646  house mouse
3S4W_B     576 VTSLLQLVHSCTeHSPWASSLYYDefanliqERKLAPKTLewVGQTIFNDFQDAFVVDfcaapegdfpfpvkalygleey 655  house mouse
Feature 1                                                           #                          
3S4Z_A     647 -----------------------gacvltqgsqifLQEPLDHLLSCIQHCLAWYksrvvplqqgdegeeeeeelyseldd 703  house mouse
3S4W_A     647 -----------------------gacvltqgsqifLQEPLDHLLSCIQHCLAWYksrvvplqqgdegeeeeeelyseldd 703  house mouse
3S4W_B     656 stqdgivinllplfyqecakdasratsqessqrsmSSLCLASHFRLLRLCVARQhdgnldeidglldcplflpdle---- 731  house mouse
Feature 1                                                                                      
3S4Z_A     704 mlesitvrmikseledfeldksadfsqntnvgiknnicACLIMGVCEVLMEYNfsisnfskskfeEILSLFTCYKKFSDI 783  house mouse
3S4W_A     704 mlesitvrmikseledfeldksadfsqntnvgiknnicACLIMGVCEVLMEYNfsisnfskskfeEILSLFTCYKKFSDI 783  house mouse
3S4W_B     732 ----------------pgeklesmsakdrslmcsltflTFNWFREVVNAFCQQtspe-----mkgKVLSRLKDLVELQGI 790  house mouse
Feature 1                                                                                      
3S4Z_A     784 lsekagkgkakmtskvsdsllslkfvsdlltalfrdsiqsheeslsvlrssgefmhyavnvtlqkiqqlirtghvsgpdg 863  house mouse
3S4W_A     784 lsekagkgkakmtskvsdsllslkfvsdlltalfrdsiqsheeslsvlrssgefmhyavnvtlqkiqqlirtghvsgpdg 863  house mouse
3S4W_B     791 lekylavipdyvppfasvdldt-----------------------------------------ldmmprktfvslqnyra 829  house mouse
Feature 1                                                                                      
3S4Z_A     864 qnpdkIFQNLCDITrvllwrytsiptsveesgkkekgksISLLCLEGLQKTFSVVLQf---------------------- 921  house mouse
3S4W_A     864 qnpdkIFQNLCDITrvllwrytsiptsveesgkkekgksISLLCLEGLQKTFSVVLQf---------------------- 921  house mouse
3S4W_B     830 ffrelDIEVFSILHsglvtkfildt---emhteatevvqLGPAELLFLLEDLSQKLEnmltapfakriccfknkgrqnig 906  house mouse
Feature 1                                                                                      
3S4Z_A     922 -----------YQPKVQQFLqaldvmgteeeeagvtvTQRASFQIRQFQRSLLNlls-------seeDDFNSKEALLLIA 983  house mouse
3S4W_A     922 -----------YQPKVQQFLqaldvmgteeeeagvtvTQRASFQIRQFQRSLLNlls-------seeDDFNSKEALLLIA 983  house mouse
3S4W_B     907 fshlhqrsvqdIVHCVVQLL-----------------TPMCNHLENIHNFFQCLgaehlsaddkaraTAQEQHTMACCYQ 969  house mouse
Feature 1                                                                                      
3S4Z_A     984 VLSTLSRLLep------------------------------------tsPQFVQMLSWTSkickeysqedASFCKSLMNL 1027 house mouse
3S4W_A     984 VLSTLSRLLep------------------------------------tsPQFVQMLSWTSkickeysqedASFCKSLMNL 1027 house mouse
3S4W_B     970 KLLQVLHALfawkgfthqskhrllhsalevlsnrlkqmeqdqpleelvsQSFSYLQNFHH----------SVPSFQCGLY 1039 house mouse
Feature 1                                                                                      
3S4Z_A    1028 FFSLHVLYks------------pVTLLRDLSQDIhgqlgdidqdveiektdhfavvnlrtaAPTVCLLVLSQAEKvleev 1095 house mouse
3S4W_A    1028 FFSLHVLYks------------pVTLLRDLSQDIhgqlgdidqdveiektdhfavvnlrtaAPTVCLLVLSQAEKvleev 1095 house mouse
3S4W_B    1040 LLRLLMALleksavpnqkkeklaSLAKQLLCRAWphgek-----------------eknptFNDHLHDVLYIYLEh---- 1098 house mouse
Feature 1                                                                                      
3S4Z_A    1096 dwliakikgsanqetlsdkvtpedassqavpptlliekaiVMQLGTLVTFFHELVQT----------ALPSGSCVDTLLK 1165 house mouse
3S4W_A    1096 dwliakikgsanqetlsdkvtpedassqavpptlliekaiVMQLGTLVTFFHELVQT----------ALPSGSCVDTLLK 1165 house mouse
3S4W_B    1099 ---------------------------------------tDNVLKAIEEITGVGVPElvsapkdaasSTFPTLTRHTFVI 1139 house mouse
Feature 1                                                     
3S4Z_A    1166 GLSKIYSTLTAFVKYYlqvc-qssrGIPNTVEKLVKLSGSHLTPVCY 1211 house mouse
3S4W_A    1166 GLSKIYSTLTAFVKYYlqvc-qssrGIPNTVEKLVKLSGSHLTPVCY 1211 house mouse
3S4W_B    1140 FFRVMMAELEKTVKGLqagtaadsqQVHEEKLLYWNMAVRDFSILLN 1186 house mouse

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