3RBY


Conserved Protein Domain Family
HRI1_N_like
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cd11692: HRI1_N_like 
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N-terminal domain of HRI1 and related proteins
Saccharomyces cerevisiae Hri1p (Hrr25-interacting protein 1, YLR301w) is a non-essential gene product named for its interaction with the yeast protein kinase Hrr25p. It has also been characterized as an interaction partner for Sec72p, but does not seem to be required for protein translocation into the ER. It may be a cytosolic protein. Hri1p contains a tandem repeat of a structural unit that forms a beta-barrel with structural similarity to nitrobindin. This N-terminal repeat is involved in homodimerization and may contain a ligand binding site.
Links
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Statistics
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PSSM-Id: 212591
Aligned: 29 rows
Threshold Bit Score: 107.818
Created: 27-Mar-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interfaceputative ligand
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:3RBY: Saccharomyces cerevisiae HRI1 forms homodimer, contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            # ##    #            ###  #                 ##                              
3RBY_A         3 PALLKRLLFQVGPh-----------PNERTFTLSSVSTDGHYISLRPFVKpsg------------delSFPFEWAFAGTn 59  baker's yeast
XP_002497084   2 PQLLKRLAFQVGSv-----------PNERTTTFTSISNDGHHISLRPLVNlnst-----------seeEFPFEWVFAGLn 59  Zygosaccharomyc...
XP_447273      3 AVLFKRLVFQVGDs-----------ANERTFTLSSVSKNGHFISLRPFTKpte------------dekKFPLEWVFAGTn 59  Candida glabrat...
XP_002556180  19 VSLNKRCTFQVGEn----------pADERTLTLSSASNGGYYISLRPFVEpkg------------sesELPYEWAFAGSp 76  Lachancea therm...
XP_452440      2 VSLTKRVLFEVIPn----------pPDETTLTLSSTTNKGHYISVRPFVNae--------------gkEFPFEWAFGGTs 57  Kluyveromyces l...
XP_003686195   2 PSLLKRVLFQVGDa-----------MNERTITYSSVSNDGHCISIRPFTKptge-----------keeKFPIEWAFACTn 59  Tetrapisispora ...
XP_001594966 294 LCQSGDISNGEQEs----------eAKENTNTLVLTSADKHYVDIRILDPskplpnn-----tsdpqaISRLEWGFAGRa 358 Sclerotinia scl...
XP_002841445   2 ANISARVSIRWLPa----------pASEPTSTLVTTAPNLQFVDLRPPASlh---------------nSTPPQWAIAGR- 55  Tuber melanospo...
XP_001910728   2 ADISIRKWIRWESh----------sPTPPTSTIVLTSPQRRFVDIRVLLPlptpp--------dselpLEQLEWAIAGTs 63  Podospora anser...
EGO58838       7 SDISIRHSIRWIPssspssssdtppPSEPTSTMVLTSPSGRFVDLRIFKEdpsspnhtsvfinpnshtGSEPDAEEAKTl 86  Neurospora tetr...

Feature 1                                                           ##      #   #                
3RBY_A        60 e------tVKANDQgn--gVVTQDFNFWLDTnvylnvpnthRGEVNTTWKNWD------SGCVEETGAVYPFGadKESVS 125 baker's yeast
XP_002497084  60 tg----vrVVPISEg----VVEQDFNFWLDTncyl---nlpNTHRGEVKTIWTqw---dSGSVAENGEVFPNGpdNPGVP 125 Zygosaccharomyc...
XP_447273     60 drv-kvtpTTNADGk---pVLQQDFDMGFDTnvyl---nveNTHRGVINTFWQnw---eSGCVEETGKVFPFGndKEGIP 129 Candida glabrat...
XP_002556180  77 ks----leAKKVDEl----RDDINFNFDFDTnvhl---naeNTHRGVVETHWKkw---eSGLVEERGQVFPFGpdKQAVS 142 Lachancea therm...
XP_452440     58 dh----ieLKKINEr----ANSLNFNFKFDTnvkl---nvpETHRGVIKTVFKtw---dSGLVEETGSVFPWGteGTEVK 123 Kluyveromyces l...
XP_003686195  60 kd----vkVTKLSEt----SMKQDFDFLLDTnryl---ageHEKSGDIVETQWdt--weSGLILEHGVVYPHGkdKEGVA 126 Tetrapisispora ...
XP_001594966 359 ist--paeFKDGDKsilikPAHTEWIHEIDNkir-----npGPDDRDEGFMYPve---gTNEVLEKGAMVNPEt-GKVED 427 Sclerotinia scl...
XP_002841445  56 --------TVVGTPm----RWVHEIDSRTDT----------PGEDSGVNTPLP------NGDILEKGRMVDDEd-DQVKD 106 Tuber melanospo...
XP_001910728  64 tss--pvlNPKTKEv---eYSHCVWSHWIDSrv------nnRDAGADEGDNYPve--ghPELTLERGRMVNPAs-GRVEG 129 Podospora anser...
EGO58838      87 plsrmdwaIAGTSTh----TSTRPTIGVLHTeagg--gpspDEAAADEGDMYRipgegnEKLALEKGRMVNPEs-GQEEE 159 Neurospora tetr...

Feature 1         #         #
3RBY_A       126 FREMWQPVDPSR 137 baker's yeast
XP_002497084 126 FFELWHPLDPNR 137 Zygosaccharomyces rouxii CBS 732
XP_447273    130 FMELWQPIDPNS 141 Candida glabrata CBS 138
XP_002556180 143 FFELWQPIDATR 154 Lachancea thermotolerans CBS 6340
XP_452440    124 FRELWQPVDPTR 135 Kluyveromyces lactis NRRL Y-1140
XP_003686195 127 FKELWQPLDCSI 138 Tetrapisispora phaffii CBS 4417
XP_001594966 428 YQELWEDLEVEM 439 Sclerotinia sclerotiorum 1980 UF-70
XP_002841445 107 YEEVWRNVDIDE 118 Tuber melanosporum Mel28
XP_001910728 130 YEEMWVAGEVRA 141 Podospora anserina DSM 980
EGO58838     160 YEEVWVPDEEGA 171 Neurospora tetrasperma FGSC 2508

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