3N6O,2WWX,3JZ9,3JZA,3L0I,3L0M,3L0M


Conserved Protein Domain Family
SidM_DrrA_GEF
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cd11689: SidM_DrrA_GEF 
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guanine nucleotide-exchange factor domain of Legionella SidM/DrrA
Effector protein DrrA of Legionella pneumophila, an intracellular pathogen, is a potent guanine nucleotide-exchange factor (GEF) specific for the host Rab1 GTPase. It competes with endogenous exchange factors to recruit and activate Rab1 on plasma membrane-derived organelle, therefore effectively hijacking the host's vesicle trafficking to avoid phagosome-lysosome fusion.
Links
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Statistics
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PSSM-Id: 212588
Aligned: 7 rows
Threshold Bit Score: 340.241
Created: 20-Mar-2012
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Rab1
Conserved site includes 43 residues -Click on image for an interactive view with Cn3D
Feature 1:Rab1 interaction interface [polypeptide binding site]
Evidence:
  • Structure:2WWX, Legionella pneumophila SidM-DrrA(GEFGDF domain)-Rab1 (GTPase domain) complex, contacts 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       #  #   #                      #  ##  ##  ## ##
3N6O_A      3 MVTRIENLENAKKLWDNANSMLEKGNiSGYLKAANELHKFMKEKNLKEDDLRPELsdktisPKGYAILQSLWGAASDYSR 82  Legionella pneumop...
2WWX_B     23 RVTRIENLENAKKLWDNANSMLEKGNiSGYLKAANELHKFMKEKNLKEDDLRPELsdktisPKGYAILQSLWGAASDYSR 102 Legionella pneumop...
3JZ9_A      3 XVTRIENLENAKKLWDNANSXLEKGNiSGYLKAANELHKFXKEKNLKEDDLRPELsdktisPKGYAILQSLWGAASDYSR 82  Legionella pneumop...
3JZA_B      3 MVTRIENLENAKKLWDNANSMLEKGNiSGYLKAANELHKFMKEKNLKEDDLRPELsdktisPKGYAILQSLWGAASDYSR 82  Legionella pneumop...
3L0I_A    152 RVTRIENLENAKKLWDNANSXLEKGNiSGYLKAANELHKFXKEKNLKEDDLRPELsdktisPKGYAILQSLWGAASDYSR 231 Legionella pneumop...
3L0M_A     28 RVTRIENLENAKKLWDNANSXLEKGNiSGYLKAANELHKFXKEKNLKEDDLRPELsdktisPKGYAILQSLWGAASDYSR 107 Legionella pneumop...
3L0M_B     28 RVTRIENLENAKKLWDNANSXLEKGNiSGYLKAANELHKFXKEKNLKEDDLRPELsdktisPKGYAILQSLWGAASDYSR 107 Legionella pneumop...

Feature 1       ###  ### ### ###### #  ##  #######                   #   ###  #               
3N6O_A     83 AAATLTESTVEPGLVSAVNKMSAFFMDCKLSPNERATPDPDFKVGKSKILVGIMQFIKDVADPTSKIwmHNTKALMNHKI 162 Legionella pneumop...
2WWX_B    103 AAATLTESTVEPGLVSAVNKMSAFFMDCKLSPNERATPDPDFKVGKSKILVGIMQFIKDVADPTSKIwmHNTKALMNHKI 182 Legionella pneumop...
3JZ9_A     83 AAATLTESTVEPGLVSAVNKXSAFFXDCKLSPNERATPDPDFKVGKSKILVGIXQFIKDVADPTSKIwxHNTKALXNHKI 162 Legionella pneumop...
3JZA_B     83 AAATLTESTVEPGLVSAVNKMSAFFMDCKLSPNERATPDPDFKVGKSKILVGIMQFIKDVADPTSKIwmHNTKALMNHKI 162 Legionella pneumop...
3L0I_A    232 AAATLTESTVEPGLVSAVNKXSAFFXDCKLSPNERATPDPDFKVGKSKILVGIXQFIKDVADPTSKIwxHNTKALXNHKI 311 Legionella pneumop...
3L0M_A    108 AAATLTESTVEPGLVSAVNKXSAFFXDCKLSPNERATPDPDFKVGKSKILVGIXQFIKDVADPTSKIwxHNTKALXNHKI 187 Legionella pneumop...
3L0M_B    108 AAATLTESTVEPGLVSAVNKXSAFFXDCKLSPNERATPDPDFKVGKSKILVGIXQFIKDVADPTSKIwxHNTKALXNHKI 187 Legionella pneumop...

Feature 1                  #             
3N6O_A    163 AAIQKLERSNnvNDETLESVLSSKGEN 189 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
2WWX_B    183 AAIQKLERSNnvNDETLESVLSSKGEN 209 Legionella pneumophila
3JZ9_A    163 AAIQKLERSNnvNDETLESVLSSKGEN 189 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
3JZA_B    163 AAIQKLERSNnvNDETLESVLSSKGEN 189 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
3L0I_A    312 AAIQKLERSNnvNDETLESVLSSKGEN 338 Legionella pneumophila
3L0M_A    188 AAIQKLERSNnvNDETLESVLSSKGEN 214 Legionella pneumophila
3L0M_B    188 AAIQKLERSNnvNDETLESVLSSKGEN 214 Legionella pneumophila

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