Conserved Protein Domain Family
HDAC10
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cd11683: HDAC10 
Histone deacetylase 10
Histone deacetylases 10 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC10 has an N-terminal deacetylase domain and a C-terminal pseudo-repeat that shares significant similarity with its catalytic domain. It is located in the nucleus and cytoplasm, and is involved in regulation of melanogenesis. It transcriptionally down-regulates thioredoxin-interacting protein (TXNIP), leading to altered reactive oxygen species (ROS) signaling in human gastric cancer cells. Known interaction partners of HDAC10 are Pax3, KAP1, hsc70 and HDAC3 proteins.
Links
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Statistics
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PSSM-Id: 212546
Aligned: 5 rows
Threshold Bit Score: 668.876
Created: 21-Feb-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activeZn binding site
Feature 1:putative active site [active site]
Evidence:
  • Comment:Active center contains inhibitor and a catalytic Zn ion that coordinates side chain atoms of two aspartates and one histidine, and a water molecule.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
Q969S8        18 WDDPECEIERPERLTAALDRLRQRGLEQRClrlsaREASEEELGLVHSPEYVSLVRETQVLGKEElq------aLSGQFD 91  human
NP_001089352  20 WDDPECSIEVPERLSSSYKRLQDYDLVKRCiqlpvREATDEEITLVHSHDYLQVVKSTQTMNEKElk------eISQKYT 93  African clawed ...
XP_515218     18 WDDPECEIERPERLTAALDRLRQRGLEQRClrlsaREASEEELGLVHSPEYVSLVRETQVLGKEElq------aLSGQFD 91  chimpanzee
NP_956069     20 WTDPACEIEVPERLTVSYEALRTHGLAQRCkavpvRQATEQEILLAHSEEYLEAVKQTPGMNVEElm------aFSKKYN 93  zebrafish
XP_415986     20 WNDPICDIEVPERLSASYEQLQCYHLVERCvpvpaREGSEEEILLVHSKYIADQFRTLGSCKSTQtmneeelkrISGNYD 99  chicken

Feature 1                                                  ##       ##                           
Q969S8        92 AIYFHPSTFHCARLAAGAGLQLVDAVltgaVQNGLALVRPPGHHGQRaaANGFCVFNNVAIAAAHAkqkhglhRILVVDW 171 human
NP_001089352  94 AVFYHQNSFRCAKLSLGGTLQLVDAIltreVQNGMAIVRPPGHHSQRnqGNGFCVFNNVAIAAEYAkkkykleRILIVDW 173 African clawed ...
XP_515218     92 AIYFHPSTFHCARLAAGAGLQLVDAVltgaVQNGLALVRPPGHHSQRaaANGFCVFNNVAIAAAHAkqkhglhRILVVDW 171 chimpanzee
NP_956069     94 DVYFHQNIYHCAKLAAGATLQLVDSVmkreVRNGMALVRPPGHHSQRsaANGFCVFNNVAFAALYAkknynlnRILIVDW 173 zebrafish
XP_415986    100 SFFFHPNTYHCARLAVGAALQLVDSVmsgkVCNGMALVRPPGHHSQRnaANGFCLFNNVAIAAEYAklkyglqRILIVDW 179 chicken

Feature 1        # #                                                                             
Q969S8       172 DVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAvGRGQGLGFTVNLPWNQVGMgNADYVAAFLHLLLPLAF 251 human
NP_001089352 174 DVHHGQGIQYIFEEDPSVLYFSWHRYEHKTFWPYLRESDYDViGRGKGTGFNINLPWNKVGMgNADYIAAFFHVLLPLAF 253 African clawed ...
XP_515218    172 DVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAvGRGQGLGFTVNLPWNQVGMgNADYVAAFLHLLLPLAF 251 chimpanzee
NP_956069    174 DVHHGQGIQYCFEEDPSVLYFSWHRYEHQSFWPNLPESDYSSvGKGKGSGFNINLPWNKVGMtNSDYLAAFFHVLLPVAY 253 zebrafish
XP_415986    180 DVHHGQGTQYIFEEDQSVLYFSWHRYEHQEFWPSLKESDYDAvGLGKGKGFNINLPWNKVGMgNSDYLAAFFHVLLPVAF 259 chicken

Feature 1                     #                                     #                            
Q969S8       252 EFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYhleSLAESVCMTVQTLLGDPAPplsg 331 human
NP_001089352 254 EFNPELVLVSAGYDSAIGDPEGRMCATPECFSHLTNMLMNLAGGKLCAVLEGGYnlrSLAESVCMTVRTLLGDPLPrltg 333 African clawed ...
XP_515218    252 EFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYhleSLAESVCMTVQTLLGDPAPplsg 331 chimpanzee
NP_956069    254 EFDPELVIVSAGFDSAIGDPEGEMCALPEIFAHLTHLLMPLAAGKMCVVLEGGYnltSLGQSVCQTVHSLLGDPTPrisg 333 zebrafish
XP_415986    260 EFDPELVLVSSGYDSGIGDPEGQMNATPEVFAHLTHFLMQLAHGKLCVILEGGYhlkSLSESVCMTVKTLLRDPLPqvtg 339 chicken

Feature 1                               
Q969S8       332 pmAPCQSALESIQSARAAQAPHW 354 human
NP_001089352 334 emTPCHSALESIQNVRAAHTPYW 356 African clawed frog
XP_515218    332 pmVPCQSALESIQSARAAQAPHW 354 chimpanzee
NP_956069    334 lgTACDSALESIQNVRNVQSSYW 356 zebrafish
XP_415986    340 emAPCLSAIESIQNVRAAHKPYW 362 chicken

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