4DIX


Conserved Protein Domain Family
SCAB1_middle
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cd11675: SCAB1_middle 
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middle domain of the stomatal closure-related actin binding protein1
SCAB1 is a dimeric actin crosslinker conserved in plants. The three-dimensional structure of this domain resembles that of fibronectin type III repeat units and immunoglobulins. It is situated between a coiled-coil dimerization domain and a C-terminal pleckstrin homology-like module. SCAB1 appears to be required for normal actin dynamics in guard cells stomatal movement. The function of the middle domain is not clear.
Links
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Statistics
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PSSM-Id: 212565
Aligned: 7 rows
Threshold Bit Score: 150.287
Created: 6-Mar-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PH domain
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:PH domain interface [polypeptide binding site]
Evidence:
  • Structure:4DIX: the middle domain of Arabidopsis thaliana SCAB1 interacts with the C-terminal pleckstrin homology-like domain, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 ###                      #        ###### # # #####                     
4DIX_A        14 VYEIDGTEALGSCLRVRPCSNdAPDLSKCTIQWYRSSsdGSKKELISGATKSVYAPEPFDVGRVLHADIIYD-GHSLSLS 92  thale cress
ACN26176     282 LYELKGLETLGSTLRIVVHECaSVDFSNSSIQWFRIQpeGSKKEIISGATKPVYAPEPHDVGRYIQAEVKSG-GQISVAK 360 Zea mays
EDQ67874     227 HFELQGEERLGSSLVIVPADSlSPELGKCKFQWHRMH--GIKAETIIGATRPQYAPEPLDVGKKLKVDIDLPdGSRESLA 304 Physcomitrella ...
NP_181614    285 PYVLDGAQSLGSCLRIRASSDsGIDISKCSIHWYRAAseSSRREAISGANRSVYAPEPFDVGRVIQADIVSN-GQKFTVT 363 thale cress
XP_002988577 255 VYRVDGTECLGSLLSLSPVDEqAPDLSSCKFQWHRISadGGKKELISGAVKSQYAPDPFDAGRILRVDITLPdGAKEFLS 334 Selaginella moe...
XP_001754501 250 HYEIQGEERLGGALVITQTNEtSVDVSKCVIQWHRIAvdGSKVCLFVGATRPQYAPEPLDVGWLLRADLTMPdGKKESVF 329 Physcomitrella ...
BAD68172     269 LYDLEGSDILGSQFCIIPRFDdAPDISSCPTQWYRVIs-GGNRNLILGATKPTYAPEPFDVGRLLQAEIVLN-AEKVTIQ 346 Japanese rice

Feature 1              
4DIX_A        93 TVGKID 98  thale cress
ACN26176     361 TAGSID 366 Zea mays
EDQ67874     305 TSGPID 310 Physcomitrella patens subsp. patens
NP_181614    364 TDGPIN 369 thale cress
XP_002988577 335 TTGPVD 340 Selaginella moellendorffii
XP_001754501 330 TTGSLD 335 Physcomitrella patens subsp. patens
BAD68172     347 TMGPIN 352 Japanese rice

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