2GTL,2GTL,2GTL


Conserved Protein Domain Family
hemoglobin_linker_C
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cd11673: hemoglobin_linker_C 
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Globular domain of extracellular hemoglobin linker
This family of hemoglobin linker chains is restricted to annelid worms, and participates in the formation of the large erythrocruorin respiratory complex. Via its N-terminal coiled-coil segment (not included in this model), the molecule forms trimers, which are part of a scaffold organizing the overall complex architecture; the latter encompasses 36 linkers and 144 hemoglobins in total. This C-terminal globular domain is involved in trimerization, and also interacts with globins and other C-terminal globular linker domains of neighboring trimers. The structure resembles that of nitrophorins and lipocalins.
Links
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Statistics
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PSSM-Id: 212563
Aligned: 12 rows
Threshold Bit Score: 109.385
Created: 10-May-2012
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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hemoglobintrimer
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:hemoglobin interaction interface [polypeptide binding site]
Evidence:
  • Structure:2GTL: Lumbricus terrestris hemoglobin linker chain contacts 3 globins in the erythrocruorin respiratory complex, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #   #                # ##  #                          #           
2GTL_O     95 TKAGDKFIGDVCFDH--CTKRRPEHMTLAFESSSIAAFFTPIADLHVHIEIEsetdedesEVSMPADGEYSFadHRLTIH 172 common earthworm
2GTL_N     96 VKAGNVFSGTSTWHG--CLAREDHVTRITITASKRRKFFTARIWLRALVESElerhgenvTSSFNAKGYYNFasRRLILL 173 common earthworm
2GTL_M     97 THVGSSYTGLATWTS--CEDLNPDHAIVTITAAHRKSFFPNRVWLRATLSYEldeh-dhtVSTTQLRGFYNFgkRELLLA 173 common earthworm
ABB71124  120 FAKGDTFVGDQEFDH--CGRFNPDHITLHIDSVTTIPFFTSHPKVTGRVDIHvdrd-ddwAVSTPSFGFYSFatHRIIFR 196 common earthworm
CAJ00866  137 TEAGSSWTGTVVYDH--CTKRRPETMKLSIKSVDTVPFFTTHPKVRGTVLMEkhtkdyseVINEPVSGYWSSa-DRSAAM 213 lugworm
P16222    105 VTANSTWIGYPAYDH--CTQRRPYEMVISITSAPSDIVYKVHQPLKVQVDLFskkgglkqSASLHGDAVYCKgsQRLIVA 182 Lamellibrachia sp.
P18208    110 PIAGTLLVGHLNTDHdfCTKRKPNEFDLFISSVQRSSYFQSRLKVKGNLQIKytaegrdqEDVLQVKGYYNFgtHQLVIL 189 Japanese palolo
P18207    133 ASVGSSFEGQIRQLDt-CTKRKPSAFRFIITNVDVPKYFPQEPHVKATILMTsskdghetQSSLAVDGVYDFthRKVILY 211 Japanese palolo
CAB38536  126 VPAGRSWNGVAHWDS--CLVRSNNKMNVLITGNKRYDYFPSRLWVDAVIIESytvsgeeqTNTWSISGFYNYasRMVKFN 203 Sabella spallanzanii
ABW24414    2 TPAGSSWGGDLEWVG--CAAHRSKRVYIVITRTWQKSYIPSIQMVAATLVFSwvedgktmTNTEQVEGHYCCgaHALKLR 79  tube worm
BAC82449  114 LAPGTQFSLRLSWTS--CENWADKHYDVHLRQLHRSKTFAGNADVVVDLVSQd------hQHRLVLKGRYTYgkKELLLL 185 North American leech
CAJ00867  113 AHAGATFKGVILNSQc-QTENVAKNMQIDIVGEKRYSDFPTISVLELLVTLD--------DHQDLYNGIYSYg-RKALVS 182 Alvinella pompejana

Feature 1                                 ##  ##         
2GTL_O    173 PPee--dGLGLVGEFDgyNFDRFVGHIVHElsEEVCAEFIFHR 213 common earthworm
2GTL_N    174 PTddhddHLAVVCSFNrgDNERAECHRVTEatLHQCADLFVTL 216 common earthworm
2GTL_M    174 PLkgqseGYGVICDFNlgDDDHADCKIVVPssLFVCAHFNAQR 216 common earthworm
ABB71124  197 TPdk--dSLYLVAQFDgyNFDRFVGETLRVgtGLPCARFIYKR 237 common earthworm
CAJ00866  214 PPds-agHLGFVCIFHghDHDTCTGLLTKGkvTDACAEFTFHR 255 lugworm
P16222    183 PPed--dRLEIIGQFDgvSNDRFKGYIVREmsGDKCAEFRFFK 223 Lamellibrachia sp.
P18208    190 PPed--dRLGIVCNFRagNDDRCRAHIVHEasLEHCGDDFVFV 230 Japanese palolo
P18207    212 SPdk--dNLIFECTFPrhDNNHCKGVMKHSg-GDVCLTFTLER 251 Japanese palolo
CAB38536  204 SPkegtmGIGLTCSDA--GSDVAQCDFVRAtdQHVCGSVTLTR 244 Sabella spallanzanii
ABW24414   80 AAng-hvGADITCNFT--DDNHCHGKIYKAatGTLCSRVILTR 119 tube worm
BAC82449  186 SDhpklkGYQFVCDFFdgKKGRAKCYIETKssLFPCGTGFLLE 228 North American leech
CAJ00867  183 FGkg-ggGLGMVCYFDtdDGKFCKAEFLSIvsKEVCGTAILTS 224 Alvinella pompejana

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