Conserved Protein Domain Family
GH38N_Man2A2
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cd11667: GH38N_Man2A2 
N-terminal catalytic domain of Golgi alpha-mannosidase IIx, and similar proteins; glycoside hydrolase family 38 (GH38)
This subfamily is represented by human alpha-mannosidase 2x (MX, also known as mannosyl-oligosaccharide 1,3- 1,6-alpha mannosidase, EC 3.2.1.114, Man2A2). MX is enzymatically and functionally very similar to GMII (found in another subfamily), and as an isoenzyme of GMII. It is thought to also function in the N-glycosylation pathway. MX specifically hydrolyzes the same oligosaccharide substrate as does MII. It specifically removes two mannosyl residues from GlcNAc(Man)5(GlcNAc)2 to yield GlcNAc(Man)3(GlcNAc)2(GlcNAc, N-acetylglucosmine).
Links
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Statistics
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PSSM-Id: 212132
Aligned: 4 rows
Threshold Bit Score: 815.378
Created: 19-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   # #  #                                                                
P49641        165 DLQVFVVPHSHNDPGWIKTFDKYYTeQTQHILNSMVSKLQEDpRRRFLWAEVSFFAKWWDNInVQKRAAVRRLVGNGQLE 244  human
NP_001085565  165 PLQVFVVPHSHNDPGWIKTFDKYYYdQTQHILNNMLVKLHEDpRRKFIWSEISFFSKWWDNInSQKRAAVRRLVASGQLE 244  African clawe...
XP_003228973  179 PLRVFVVPHSHNDPGWIKTFDKYYFdQTQHILNSMVAKLQEDpRRRFLWSEVSFFAKWWDNIsAQKRAAVRRLVGNGQLE 258  green anole
XP_001233608  163 PLQVFVVPHSHNDPGWIKTFDKYYYdQTQHILNSMVLKMQEDpRRRFIWSEISFFSKWWDNIsAQKRAAVRRLVGNGQLE 242  chicken

Feature 1                                                     # #                     #           
P49641        245 IATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAA 324  human
NP_001085565  245 MTTGGWVMPDEANTHYFAMIDQMIEGHQWLKKNIDVTPRSGWAVDPFGHSSTMPYILRLSNLTSMLIQRVHYSIKKHFAA 324  African clawe...
XP_003228973  259 MATGGWVMPDEANSHYFAMIDQLIEGHQWLEKNIGVTPRSGWAVDPFGHSATMPYILRRANLTSMLIQRVHYAIKKHFAA 338  green anole
XP_001233608  243 MVTGGWVMPDEANSHYFAMIDQLIEGHQWLEKNIGVTPRSGWAVDPFGHSSTMPYLLKRSNLTGMVIQRVHYAIKKHFAA 322  chicken

Feature 1                                    # #   #     #         #        ##                    
P49641        325 THSLEFMWRQTWDsDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRlpggRINCPWKVPPraITEANVAERAALLL 404  human
NP_001085565  325 TQSLEFMWRQTWDpDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFRRlpggRINCPWKVPPraITDSNLAERAIILL 404  African clawe...
XP_003228973  339 TKSLEFMWRQSWDpDSSTDILCHMMPFYSYDVPHTCGPDPKVCCQFDFKRlpggRINCPWKVPPkaITSTNVAERAQLLL 418  green anole
XP_001233608  323 TQNLEFMWRQTWDpESSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRlpggRINCPWKVPPraITEANVAERAQLLL 402  chicken

Feature 1                             ## #                                                        
P49641        405 DQYRKKSQLFRSNVLLVPLGDDFRYdkPQEWDAQFFNYQRLFDFFNSrpnLHVQAQFGTLSDYFDALYKRTGVepgarpp 484  human
NP_001085565  405 DQYKKKSKLYRSKVVLVPLGDDFRYdkIQEWDAQFLNYQKLFDYMNShpeLHVQAQFGTLSDYFDALYKRMGVspgmkpp 484  African clawe...
XP_003228973  419 DQYRKKSKLYRSKVLLVPLGDDFRYdkPQEWDAQFLNYQRLFDFLNAhpdLHVQAQFGTLSDYFDALYKSTSVvpgvqpp 498  green anole
XP_001233608  403 DQYRKKSKLYRSKVLLVPLGDDFRYdkPQEWDAQFLNYQRIFDFLNAqpqLHVQAQFGTLSDYFDALYKRVGIvpgmrpp 482  chicken

Feature 1                            #    
P49641        485 gFPVLSGDFFSYADReDHYWTGYY 508  human
NP_001085565  485 dFPVVSGDFFSYADReDHYWTGYY 508  African clawed frog
XP_003228973  499 gFPVVSGDFFSYADReDHYWTGYY 522  green anole
XP_001233608  483 gFPVLSGDFFSYADReDHYWTGYY 506  chicken

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