3K6G


Conserved Protein Domain Family
TRF2_RBM
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cd11654: TRF2_RBM 
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RAP1 binding motif of telomere repeat binding factor
TRF2 (Telomere repeat binding factor 2) functions as part of the 6-component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminus (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA-binding proteins (TRF2, TRF1 and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM) described by this model, the TIN2 binding motif (TBM), and a myb-like DNA binding domain.
Links
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Statistics
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PSSM-Id: 212553
Aligned: 44 rows
Threshold Bit Score: 60.8497
Created: 10-May-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimer
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:RAP1 is recruited to telomeres via binding to TRF2
  • Comment:RAP1 C-terminus (RCT) binds to the TRF2 RAP1-binding motif (RBM)
  • Structure:3K6G: human TRF2 binds RAP1, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #####    ## ### ###        #  ######   
3K6G_D         1 QLRNPPTTIGXX----TLKAAFKTLSGAQDSEAAFAKLDQKDLVLP 42  human
EHH31802     202 QLRNPPTTIGMM----TLKAAFKTLSGAQDSEAAFAKLDQKDLVLP 243 rhesus monkey
EHH60520     207 QLRNPPTTIGMM----TLKAAFKTLSGAQDSEAAFAKLDQKDLVLP 248 crab-eating macaque
XP_002193258 382 QPPGAVTSCGIS----VLREAFKILSDSGDPDTLFTKLDETDLPCP 423 zebra finch
CAB56220     492 TPFRTVTTYGIS----VLREAFKMLSNSPDSDALFNKLDETDLPSP 533 chicken
Q9PU53       494 TPFRTVTTYGIS----VLREAFKMLSNSPDSDALFNKLDETDLPSP 535 chicken
XP_001378172 276 PLPESPATFGIS----TLKKAFKSLSDSQDPDAAFTKLDQKDVILA 317 gray short-tailed opossum
NP_001137398 246 QVVSSEADCVISyglsVLKSKFMSLCQEEDTDTMFRKLCETDFCRK 291 western clawed frog
XP_003228470 101 RPLERPTSYGFS----VIRQAFEILSDSEDPDATFQKLDETDWTFP 142 green anole
ACC76744     246 QVVSSEADCVISyglsVLKSKFKSLCQEEDPDTIFRGLCETDFCRQ 291 African clawed frog

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