3BOY,1WMQ


Conserved Protein Domain Family
HutP
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cd11640: HutP 
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Histidine Utilizing Protein, the hut operon positive regulatory protein
The HutP protein family regulates the expression of 'hut' structural genes in Bacillus and other bacteria. It forms an anti-termination complex, which recognizes three UAG triplet units, separated by four non-conserved nucleotides on the RNA terminator region. In an L-histidine and Mg2+ dependent manner, HutP binds to the nascent hut mRNA leader transcript, and the ensuing anti-termination complex inhibits formation of a stem-loop terminator, clearing the way for transcription of the hut structural genes.
Links
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Statistics
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PSSM-Id: 212163
Aligned: 32 rows
Threshold Bit Score: 112.304
Created: 23-Feb-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:3BOY: Bacillus subtilis HutP binds hut mRNA, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                 #####            #  ##  #              
3BOY_A         5 ERRIGRLSVLLLLNea----eESTQVEEle--rdGWKVCLGKVGSMd-----aHKVIAAIETASKKSGVIQSegYRESHA 73  Bacillus subtilis
ADO76407      17 SQSIGKVAVLLSMVndefdkeIIDSYKNe-----GYKAVITRAGGKgsk--lkDKVLRNCLGAAIKGDVITEs-VQDQRI 88  Halanaerobium p...
ZP_06266359   56 TGDIAKAALYLALSeg---igEERRIKEals-acGWCGVATEVGGIsge--laVKASRALVGAALNSGVVCKs-TAEMHA 128 Synergistetes b...
YP_004972936  11 KPSLERSALLLAMTet---reEEEKIKKslyseyDLRCGVTELGGTvanlqhtGKLTNSVIATAFNTGVIPKe-DRKIHA 86  Desulfosporosin...
BAE93899      11 KPSLERAAMMLAMSet---reSEFRLRQyygetwHLPCVVTEVGGTigalqtsGKLTNSVVTAALKAKVIESk-PENVHA 86  Heliobacterium ...
ZP_01666362   13 IRSVATAAMLLALTrt---isDEETVKKmla-dkGYRFVVTEVGGKssltefqEKTTKAVIGAALNSGIIGKs-ATNYHA 87  Thermosinus car...
YP_004820435   5 NLTVAKGAIVLSLSsn---reEEEEIKKlll-ekGYKCAVTELGGKsse--fnEKIVSAVVGAALNNNVIEKn-PTSMHA 77  Thermoanaerobac...
YP_003579798   5 ADRIGKAAIMAAISsr----eEEDLIKEqilahpTWKVGITYVTGRrse--ieKGFVKSIVACALNGGVIHNr-PGAVHG 77  Rhodobacter cap...
YP_486893     17 ADRIGKVAIMLAMTse----eEEASFKAkisketNYKFSVTWVSGRkte--inKTFPRSILNAALKHGTIEDr-SGATHA 89  Rhodopseudomona...
ZP_06267103   13 EADLCRLVILLAMTpnq--dvEKEVIAQyq--klGLRSAATMISGFgid--sqTSIVRSVVNLCLNTNVIERk-RSHVHP 85  Synergistetes b...

Feature 1                                ####                         #        #           
3BOY_A        74 LYHATMEALHGVTRgemllgsLLRTVGLRFAVLRGnpyeseaegDWIAVSLYGTIGAPikgLEHETFGVGINHI 147 Bacillus subtilis
ADO76407      89 LTRCVERAMIDFDKpl----sGISGAGIKIGIVSKe--------PHLAVALYGKLGIPgldVDHEISGMGIHYY 150 Halanaerobium praeval...
ZP_06266359  129 LMHAAQEAFNVFIPgg----lLEMSIGAKIAIVRNa--------QWLAVAVAGDAAFHa-vAHHGRVGVGVMHL 189 Synergistetes bacteri...
YP_004972936  87 LIHATLEASNSIFIht----nSNASFALKIGLTTDs--------EWIAVAIYGRSSLHp-lLEHARVGLGMMHL 147 Desulfosporosinus ori...
BAE93899      87 VIHATIEALKGIFLdy----aQNASLALKISVISDg--------KWLAVGIFGKSSVHp-lTEHCRVGLGFMHL 147 Heliobacterium chlorum
ZP_01666362   88 LLHATDEAKRGIMVnv----aSSVSLAVKIAIVRDd--------SWIAVALFGDSALHp-lTNHERAGLGVMHL 148 Thermosinus carboxydi...
YP_004820435  78 LLHATIEAVKSLSLtl----pLDVSLMMKIAVVADn--------SWIAVSMFGKSALHp-lTNHERLGFGIMHL 138 Thermoanaerobacter wi...
YP_003579798  78 VIHAGLECLQGVSAtv----vAESNLKLKVALVSDg--------HWVAVAAHGESAFHp-tTNHERIGFGVMHI 138 Rhodobacter capsulatu...
YP_486893     90 LIHAGLEALSGLIPtv----pGDSSLKVKVVIIADg--------HWVVVAAYGESAFLp-eTNHERIGLGVMHL 150 Rhodopseudomonas palu...
ZP_06267103   86 ICHCVLETAQSTRAsd----aIGQNFCFKAAVVRRr--------EEFTLCFYGNLAMHe-lSGHKSIGVGYQIL 146 Synergistetes bacteri...

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