Conserved Protein Domain Family
HR1_Rhophilin-2
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cd11634: HR1_Rhophilin-2 
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-2
Rhophilin-2 is a scaffolding protein that functions as an effector of the Rho family of small GTPases. It plays a role in regulating the organization of the actin cytoskeleton. Rhophilin-2 contains an N-terminal HR1, a central Bro1-like, and a C-terminal PDZ domain; all are protein-interacting domains. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family; Rhophilin-2 has been shown to bind both RhoA and RhoB.
Links
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Statistics
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PSSM-Id: 212024
Aligned: 4 rows
Threshold Bit Score: 158.259
Created: 8-Feb-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Rhoputative Rho
Feature 1:putative Rho binding site 1 [polypeptide binding site]
Evidence:
  • Comment:based on the structure of the human PKN HR1 domain and RhoA complex
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #  #  ##  ## ##  ## ##              ##  #  ##  #                  
Q6TNR1        27 PFAQTGRSKLQNKRAVLNQKIIKQMRMRAGAENLLKATSNNKvREQVVLELSYVNSDLQLLMEQLEGLNSSVEVYQNVQE 106 zebrafish
NP_001088054  26 SIAQTGRSKLQNQRAILNQQILKAMRMRAGAENLLRATANNKiREQVLLELSFVNSNLQRLKEELERLNISVEVYQHTEQ 105 African clawed ...
XP_414133     23 PLAETGRSKLQNQRAVLNQQILRAVRMRAGAENLLRATTNNKvREQVLLELSFVNSDLQILKEELEGLNISVEVYQNTEE 102 chicken
BAG53600      27 PLAQTGRSKLQNQRAALNQQILKAMRMRTGAENLLKVATNSKvREQVRLELSFVNSDLQMLKEELEGLNISVGVYQNTEE 106 human

Feature 1          
Q6TNR1       107 SS 108 zebrafish
NP_001088054 106 AS 107 African clawed frog
XP_414133    103 TF 104 chicken
BAG53600     107 AF 108 human

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