Conserved Protein Domain Family
HR1_Rhophilin-1
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cd11633: HR1_Rhophilin-1 
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-1
Rhophilin-1 is a scaffolding protein that functions as an effector of the Rho family of small GTPases. It has been implicated in sperm motility. Rhophilin-1 contains an N-terminal HR1, a central Bro1-like, and a C-terminal PDZ domain; all are protein-interacting domains. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family; Rhophilin-1 binds RhoA was isolated initially as a RhoA-binding protein.
Links
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Statistics
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PSSM-Id: 212023
Aligned: 9 rows
Threshold Bit Score: 132.265
Created: 8-Feb-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Rhoputative Rho
Feature 1:putative Rho binding site 1 [polypeptide binding site]
Evidence:
  • Comment:based on the structure of the human PKN HR1 domain and RhoA complex
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #  #  ##  ## ##  ## ##              ##  #  ##  #               
NP_001008116  24 GCDPFAQTQRSKLQHRRARINQQINKEMRMRAGAENLFRATTNHKVRETVALELSYVNSNLQLLKEELEELNSSVEIYQN 103 western clawed ...
XP_418410     35 GCDPFAQTQRSKLQHRRARINQQINKEMRMRAGAENLFRATSNHKVKETVALELSYVNSNLQLLKEELEELNSCMDVYQN 114 chicken
CAF91185       5 GCDPLTLTQRSKLQHRRARINQQINKEMRMRAGAENLFRATTNSRVKQTVALELSFVNSNLQLLKEELEELNSNMEVYQT 84  spotted green p...
XP_002435502  24 GSDPRAATCRGKLQYRRSKINHEITKQMMMRNGAEKLFKATTNKKLRETVALELSFLNSNLQLLKEQLAELNSSVQIYQS 103 black-legged tick
XP_002122928  15 GCNPVMATQRSKMQSQRTGINQRLNKQMRLRAGAENLFNATNNPKVKETVALELSFVNSNLQLIKEELSELNSTVDPYQS 94  Ciona intestinalis
XP_785878     11 GCDPLNQTMRSKMQNRRQRLNQQINKEMRMRVGAENLFKAASNRKLKEQVALELSFVNSNLQLLKEELAEINSDVEAYQN 90  purple urchin
EFX87285       1 GSDPRAATCRSKLQSKRAKLNQEINKELRLRAGAENLFKATSNKKLRETVSLELSFVNSNLQLLKEQLAVLNSSVEVYQG 80  common water flea
NP_511168     34 GSDPRAATCRSKLQNRRCKLNKEINKELRLRAGAENLYKATSNRKLRDTVALELSFVNSNLQLLKEQLAELNSSVEIYQS 113 fruit fly
Q8TCX5        21 GCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRH 100 human

Feature 1             
NP_001008116 104 ESDAI 108 western clawed frog
XP_418410    115 DSESI 119 chicken
CAF91185      85 DSETI 89  spotted green pufferfish
XP_002435502 104 ENQSQ 108 black-legged tick
XP_002122928  95 TSGKT 99  Ciona intestinalis
XP_785878     91 DSYMR 95  purple urchin
EFX87285      81 DQHGG 85  common water flea
NP_511168    114 ESHNG 118 fruit fly
Q8TCX5       101 GSEAV 105 human

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