3R90


Conserved Protein Domain Family
MCT1_N
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cd11609: MCT1_N 
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N-terminal domain of multiple copies T cell malignancies 1 and related proteins
This N-terminal domain of MCT-1 (multiple copies T cell malignancies 1), also known as MCTS-1 (malignant T cell-amplified sequence 1), co-occurs with a PUA domain. MCT-1, together with DENR (density regulated protein), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.
Links
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Statistics
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PSSM-Id: 211422
Aligned: 61 rows
Threshold Bit Score: 88.7456
Created: 22-Feb-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PUA domain
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:PUA domain interface [polypeptide binding site]
Evidence:
  • Comment:Interactions with neighboring (C-terminal) PUA domain
  • Structure:3R90: Human N-terminal domain of MCT-1 touches the neighboring PUA domain, contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    ##                                       # #       #
3R90_A         4 KFDEkENVSNCIQLKTSVIKGIKNQLIEQFPgiepwLNQIMPKKDPVKIVRCh--eHIEILTVngELLFFRQr----EGP 77  human
EGX53642       1 MFKKpVSSSGKTKIKSSVQRNIRQKICEQFPllepvIDDVLPKKAQLDLIKAp--eKISLYALdnQVLFFQHh----NDA 74  Arthrobotrys ol...
P89886         3 KKFTrEDVHSRSKVKSSIQRTLKAKLVKQYPkiedvIDELIPKKSQIELIKCe--dKIQLYSVdgEVLFFQK-----FDE 75  Saccharomyces c...
EFX00530       1 MFKKdISSAPPQKLKTSVQRSLRQSLLSTYPllapyADELLPKKASLQSIKLp--dRAVLYVLdhEPLFFESgk-pgDVP 77  Grosmannia clav...
GAA89584       1 MFKKdIPPSNRSKVKSSVQRGLRQRFLDTYPgfepyIEEVLPKKAQLDAVKLp--eRSTLYTYenTPLFYQPl----DGP 74  Aspergillus kaw...
P87313         4 RFNSrEDIKGTTPIKSSIQRGIKAKLVQAYPnlkqvIDELIPKKSQLTQIKCe--dRLFLYTLngEIILFQHf----DGP 77  Schizosaccharom...
CBX92669       1 MFKKdITSGAKSKVKSSAQRAIRSKVLEEYPrlepyIEDIMPKKEQLDLVKLp--dRVSLYTLhsTPLFFQHm----DDA 74  Leptosphaeria m...
XP_002836252   3 TAICrFTGSSKTNLKSSVQRSLRAKLVEQFPllaphIDEILPKKSQLSLLKAp--eRLSLYALgnEVLFFQHh----DDA 76  Tuber melanospo...
XP_500162     86 KKFShENINSKANVKSSSQRALKAKLVAQFPdmepvVDQIIPKKAQLVHVKCq--dRISLYTIdgKVMFFQHf----DDE 159 Yarrowia lipoly...
XP_360061      1 MFKTsLTASPKQKVKSSAQRAVRQQLLERYPlltpfIDEILPKKSSLEQMKLphpdRVMLYVIdgQPVCFQYdlpsgGTA 80  Magnaporthe gri...

Feature 1        ###
3R90_A        78 FYP 80  human
EGX53642      75 IMP 77  Arthrobotrys oligospora ATCC 24927
P89886        76 LIP 78  Saccharomyces cerevisiae S288c
EFX00530      78 LLP 80  Grosmannia clavigera kw1407
GAA89584      75 PIP 77  Aspergillus kawachii IFO 4308
P87313        78 IIP 80  Schizosaccharomyces pombe 972h-
CBX92669      75 LLP 77  Leptosphaeria maculans JN3
XP_002836252  77 LFP 79  Tuber melanosporum Mel28
XP_500162    160 LVP 162 Yarrowia lipolytica CLIB122
XP_360061     81 ILP 83  Magnaporthe grisea 70-15

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