Conserved Protein Domain Family
DENR_C
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cd11607: DENR_C 
C-terminal domain of DENR and related proteins
DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.
Links
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Statistics
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PSSM-Id: 211320
Aligned: 58 rows
Threshold Bit Score: 81.8348
Created: 22-Feb-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative rRNA
Feature 1:putative rRNA binding site [nucleic acid binding site]
Evidence:
  • Comment:by similarity to other members of this family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #  ## #                         #  ### ### #              #  #         
AAC02985     158 QKVTIAKIPRAkKKYVTRVCGLAt--------FEIDLKEAQRFFAQKFSCGASVTGe-----DEIIIQGDFTDDIIDVIQ 224 human
CBN80022     125 QRVVIGRLSRNrRKFVTVVGGLDt-------fPDVKIKDAAKKIGKQFACGSSVSKaps-gaEEVVIQGDVLMDLPGFLE 196 Ectocarpus sili...
XP_003081993  85 KEVVITRMSRNrRKMITNVAGLEk--------FDVDLKEASKAFGKKFACGCSVTKgat-gkDELDLQGDYSEQLGELIV 155 Ostreococcus tauri
XP_002140034 101 KIVTVKVESRArRKSVTVVTGLEl--------FDISLSEAAKKFAKHFSCGSSVVKgingkvDHIDVQGDFYTTIADFIL 172 Cryptosporidium...
XP_002670080 139 RELLIRIDKRSkRKRLTLITGIEafmedafrgDEKFFKDVVKIFGKKFACGCSIVKkp---eLSIEIQGNVPGKVAKYFT 215 Naegleria grube...
ABK21810     100 PEVVVEKVVRNkRKCVTIVKGLDm--------FGIKLSDASKKLGKKFASGASVVKgpt-ekEQIDVQGDILYDIVEFIT 170 Sitka spruce
CAB87663     135 QEVIIEKVVRNkRKCITIVKGLEl--------FGIKLSDASKKLGKKFATGASVVKgpt-ekEQIDVQGDIIYDIVEFIT 205 thale cress
XP_001347141 140 EMVYIKVKERNrSKFITTLTGLEk--------HGLDIKEAQKKISKKFGCGSSINEk-----GDIELQGDLSAELEEWLP 206 Paramecium tetr...
EGZ13225     252 CMVTISKSSRKgRKRLTFVTGLEd-------fEGVNIKDACKSMGKKFACSSSLSKtdq-gqQQIQLQGDCVTELLEVLP 323 Phytophthora sojae
CCA26978     180 SPITISTSSRKgRKHVTIICGLEdy-----veEPMTIKDAAKKLGKRFACSASIIKndv-gaQQVQLQGECQVELMQVLP 253 Albugo laibachi...

Feature 1                       
AAC02985     225 EKWpevdDDSIEDLG 239 human
CBN80022     197 TTLni-pAAKISVLS 210 Ectocarpus siliculosus
XP_003081993 156 KTYdvsaEDLRFVDK 170 Ostreococcus tauri
XP_002140034 173 KTYpqieTNNIIIQS 187 Cryptosporidium muris RN66
XP_002670080 216 KELgv-dINQIYVLE 229 Naegleria gruberi strain NEG-M
ABK21810     171 ETWpnvpENAIYFIE 185 Sitka spruce
CAB87663     206 DTWpdvpERSIFFIE 220 thale cress
XP_001347141 207 KEYptikEDMIAIQE 221 Paramecium tetraurelia strain d4-2
EGZ13225     324 EMFgv-hEDQIVVVD 337 Phytophthora sojae
CCA26978     254 EMFdv-dERTIIVSD 267 Albugo laibachii Nc14

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