3LYR,3MLP,3MLN,3MLO


Conserved Protein Domain Family
COE_DBD
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cd11606: COE_DBD 
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Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.
Links
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Statistics
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PSSM-Id: 212156
Aligned: 21 rows
Threshold Bit Score: 318.608
Created: 14-Mar-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingZinc binding
Conserved site includes 29 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:COE_DBD binds DNA and activates transcription
  • Structure:3MLN: Mouse COE_DBD domain binds DNA, contacts at 4.0A
  • Structure:3MLO: Mouse COE_DBD binds DNA as a dimer, contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       #####                                            
3LYR_A        28 GVLDAnt---aAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEkeansEKTNNGIHYR 104 human
3MLN_B        12 GVLDAnt---aAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEkeansEKTNNGIHYR 88  house mouse
XP_782395     33 GWMQPtmv-dqSASSCGMARAHFEKQPPSNLRKSNFFHFVIALYDRAGQPIEVERTSFVDFIEKErepdaTKTNNGIHYR 111 purple urchin
NP_001158446  26 GWMQPtmveqgAASGVGLARAHYEKQPPSNLRKSNFFHFVIALYDRQGQPVEIERTSYIDFIEKErepdnQKTNNGIHYR 105 Saccoglossus ko...
ADQ39028      35 NWIQPtv--vdQGGSAGLGRAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEVERTAFIDFVEKDqesegQKTNNGIHYR 112 Haliotis asinina
ADQ39029      40 SAVDQa----aATASVGLGRAHYEKQPPSNLRKSNFFHFVLALYDRQGQPVEVERTAFIDFVEKEre-peGKTNNGIHYR 114 Capitella sp. I...
AAM50962      52 WAMQPv----vDQSNLGIGRAHFEKQPPSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDsesdaTKTNNGIQYR 127 fruit fly
CBH20111      89 SAHHA------HQQSPGLGRAHYEKQPPSNLRKSNFFHFVLAFYDRTGQPIEIERTAFVGFIEKEseqdgQKTNNGIHYR 162 Parhyale hawaie...
NP_510453     41 PIIDT------SNTSTQIARAHFEKHPPNNLRKSNFFHFVIALYDRNSQPIEVERTQFAGFVEKEkevdgQDTRNGIHYR 114 nematode
GAA34713     210 GVHRYs----qRPPRMEVVSARFEKQPPNNLRKSNFFHFVIALYDQNRHPIEVERAAFVDFVEKDkepegEKTNNGIHYR 285 Clonorchis sine...

Feature 1                                                     #  ####     #### #                 
3LYR_A       105 LQLLYSNGIRTEQDFYVRLIDSXTKQAIVYEGQDKNPEXCRVLLTHEIXCSRCCDKKSCGNRNETPSDPVIIDRFFLKFF 184 human
3MLN_B        89 LQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFF 168 house mouse
XP_782395    112 IQMLFHNGVRTEQDLYVRLIDSMTKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFF 191 purple urchin
NP_001158446 106 LQLLYNNGIRSEQDIYVRLIDSITKQPIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKLF 185 Saccoglossus ko...
ADQ39028     113 IQLLYANGVRQEQDLYVRLIDSVSKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFF 192 Haliotis asinina
ADQ39029     115 LQLLYANGVRQEQDLYVRLIDSVTKQAIIYEGQDKNPEMCRCLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFF 194 Capitella sp. I...
AAM50962     128 LQLLYANGARQEQDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFF 207 fruit fly
CBH20111     163 LQLLYSNGVREERDFYVRLVDASTKQAIAYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFF 242 Parhyale hawaie...
NP_510453    115 LSLMFQNGIRSEHDLFVRLIDSSTKQAITYEGQDKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFF 194 nematode
GAA34713     286 ARLIFSNGLQQDQDLYVRLVDSATKQPIAYEGQDKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVVLDRYFLKFF 365 Clonorchis sine...

Feature 1             # # #####                           # ######       
3LYR_A       185 LKCNQNCLKNAGNPRDxRRFQVVVSTTvNVDGHVLAVSDNXFVHNNSKHGRRARRL 240 human
3MLN_B       169 LKCNQNCLKNAGNPRDmRRFQVVVSTTvNVDGHVLAVSDNMFVHNNSKHGENLYFQ 224 house mouse
XP_782395    192 LKCNQNCLKNAGNPRDmRRFQVVISTTpNVDGHVLAMSDNMFVHNNSKHGRRARRL 247 purple urchin
NP_001158446 186 LKCNQNCLKNAGNPRDmRRFQVVISTTpNVDGHVLAVSDNMFVHNNSKHGRRARRL 241 Saccoglossus kowalevskii
ADQ39028     193 MKCNQNCLKNAGNPRDmRRFQVSVCTNvAIDGPLLAVSDNMFVHNNSKHGRRARRL 248 Haliotis asinina
ADQ39029     195 MKCNQNCLKNAGNPRDmRRFQVSIGTSsSVEGPLLAVSDNMFVHNNSKHGRRARRL 250 Capitella sp. I Grassle & Grassle, 1976
AAM50962     208 LKCNQNCLKNAGNPRDmRRFQVVISTQvAVDGPLLAISDNMFVHNNSKHGRRAKRL 263 fruit fly
CBH20111     243 LKCNQNCLKNAGNPRDmRRFQVVISTQvDVSGPLLAVSDNMFVHNNSKHGRRAKRI 298 Parhyale hawaiensis
NP_510453    195 LKCNQNCLKNAGNPRDmRRFQVVLCSSaRIDGPLLAVSDNMFVHNNSKHGRRTKRT 250 nematode
GAA34713     366 MKCNQNCLKNAGNPRDmRRFQVAISCSpAIERKLLCISDNMFVHNNSKHGRRTRRV 421 Clonorchis sinensis

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