3TUO


Conserved Protein Domain Family
SATB1_N
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cd11585: SATB1_N 
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N-terminal domain of SATB1 and similar proteins
SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.
Links
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Statistics
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PSSM-Id: 211426
Aligned: 15 rows
Threshold Bit Score: 145.166
Created: 24-Feb-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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tetramer
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Structure:3TUO: The N-terminal domain of human SATB1 forms homotetramer, contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # #                           ##### #                               # #  ##    
3TUO_B          8 LPVFCVVEHYEnai-----------eydCKEEHAEFVLVRKDMLFNQLIEMALLSLGYsHSSAAQAKGLIQVgKWNPVPL 76   human
ADM49195       61 IPVFCVVEQMDggmi---------sdgeSREEHAEFVLVRKDILFTQLVETALLALGYsHSSAAQAHGIIKVgRWNPLPI 131  zebrafish
NP_001073631   58 LPVFCMVEQSDvpp-----------segKRSEHAEFVLLKKDLLFSQITEAALQELGYtHTAAALATGQIQVgHWNPVAL 126  zebrafish
NP_001024985    2 FPMRVIVETVRsqhcl-------tcsneGHMITDTYAIVAGTTTLNQLVETVLAALGH-SSMSTSARGLIQVnNWKPLPF 73   nematode
EHJ77379       21 LPVHCVVEAVAsleeg-------vwrrrAVVETDSYVIIPAATAFHELVPAAMMRLGYpHELAASAKGSVVInNWKPLPF 93   monarch butte...
XP_967929      98 LPVHCIVEAICtldenral-qhgawrrrPMVETDSYVIIPVGTPFHSLVQAALLRLGYsADSAAAAKGSVVIkNWKALNF 176  red flour beetle
XP_002430868   29 LPVHCIVETILsleeqndnreknnwrrkSNVEIDSYVIIPVNTPIQELVLVALTRLGYpKESAASAKGAILIrNWRALSF 108  human body louse
EFN79495       20 LPVHCVVETIHnivesqvs-nsrekwrsPQVETDSYVIIPVAMPFQDLVGEALVRLGYsSDLIPSARGSIVIrNWKPLPM 98   Harpegnathos ...
CAA09729      249 LPLHCVVESVHslhasltidtrqpwkrrPNIETDSYVIIAAXTPWSEIVQTALQRLGYsQEVANTARGSLIIkHWKPIPL 328  fruit fly
XP_001947278   63 IPVHCIVESINhvyqwsqkhspsvhrpkGHVELDRFVIIPNNTAFRDLTEAALVRLGYsKDTAAASKGLVVLkNWLPLDL 142  pea aphid

Feature 1          ####       ##  ### ##     
3TUO_B         77 SYVTDaPDATVADMLqDVYHVVTLKIQ 103  human
ADM49195      132 HYLTDaPEATVADMLlDVYHMVTLRIQ 158  zebrafish
NP_001073631  127 SSVTDvSDATVGDMLqDLYHVITLRIK 153  zebrafish
NP_001024985   74 DQITEnLDDTVENLFkDISSHVVLKIL 100  nematode
EHJ77379       94 ERISDgPLATVGEVLgELTTVATLRIQ 120  monarch butterfly
XP_967929     177 EQISDdPLVTVGDILgELTTIATLRIQ 203  red flour beetle
XP_002430868  109 DTISPgPMVTVGELLsELSTIATLRIQ 135  human body louse
EFN79495       99 EKVADgPLLTVGDILaELTSVATLKIQ 125  Harpegnathos saltator
CAA09729      329 EQISDnPAVPVSDIVgELTSVITLRIV 355  fruit fly
XP_001947278  143 DTIAEdPVLTVNDVLgELTTLATLRIL 169  pea aphid

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