3M03


Conserved Protein Domain Family
Orc6_mid
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cd11583: Orc6_mid 
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Middle domain of the origin recognition complex subunit 6
Orc6 is a subunit of the origin recognition complex in eukaryotes, and it may be involved in binding to DNA. This model describes the central or middle domain of Orc6, whose structure resembles that of TFIIB, a DNA-binding transcription factor. Orc6 appears to form distinct complexes with DNA, and a putative DNA-binding site has been identified.
Links
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Statistics
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PSSM-Id: 211425
Aligned: 35 rows
Threshold Bit Score: 68.0883
Created: 24-Feb-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative DNA
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: putative DNA binding site [nucleic acid binding site], 2 residue positions
Conserved feature residue pattern:[RK] [RK]Click to see conserved feature residue pattern help
Evidence:
  • Comment:site-directed mutagenesis in these positions of the human Orc6 abolishes DNA-binding
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                  #                     
3M03_A         2 SNIGIRDLAVQFSCIEAVNMASKILKSYESSlpqt---------------qqvDLDLSRPLFTSAALLSACKil-kLKVD 65  human
CCA22404      91 VRFSATALCIRYGCSTIANLVIAVYEEYREValrllrnrr----gakgcgqtgLIEYNDPIYAAACLYACSKha-kLHVD 165 Albugo laibachi...
EFW44023      91 HRIDLRDLAIQMNCTDLLPQLKEFANRYREAlveeqpva------sanpsdlfETAMSKPAVLAAVFYAGCRvm-kFRVS 163 Capsaspora owcz...
NP_596222    106 LMETITYLCTKLGGSTAIPYVKQLVKAVVTNdmri--------------ehkrGIIIAAYLLVSAKAFGKDElh-iNHTE 170 Schizosaccharom...
XP_002683356 136 FAISLDDLILTFGCQGIRGSCEKLLEEYKKKfesrys-----------aeilkKTDFTKPILKVAAFYITATqtykFKVD 204 Naegleria grube...
EGZ13388      90 VQTSPAALCIKFGCEGITEIVNRVLDEYRAYlgqvaaanrkkrakhplgpavaTMNDRDPVFVAACLYAVSKha-kMNVN 168 Phytophthora sojae
AAB68869     263 RGRIPNSLLVKKYCKMTTEEIIRLCNDFELPr--------------------eVAYKIVDEYNINASRLVCPwq-lVCGL 321 baker's yeast
CCE90640     266 STRPDICLLRKRYYKVTPAETIDLCNQFEIPk--------------------dVAYSILDHYMAYASFLVCPwq-lVCGL 324 Torulaspora del...
CCD23469     276 RPYSKMCLLSRKYYKVKPIEVIELCNQFELPq--------------------dVAYNVLEQYMSYASYLVCPwq-lVCGL 334 Naumovozyma dai...
CCE64655     295 LKLGTSNMLTRKYSKIAPASVILLCNMFELPk--------------------tVAYNLLDQFMMLSSYLVCPwq-lVCGL 353 Tetrapisispora ...

Feature 1                       #                  
3M03_A        66 KNKMVAts-----gvKKAIFDRLCKQLEKIGQQV 94  human
CCA22404     166 KESLLKdv-----laNDQTFESILTSIEHHCKDI 194 Albugo laibachii Nc14
EFW44023     164 RRKIIHac-----diGETEFRNVLAKVESVIGVG 192 Capsaspora owczarzaki ATCC 30864
NP_596222    171 RRKAQSvl------qDTSSALQIQYWMHVLSESW 198 Schizosaccharomyces pombe 972h-
XP_002683356 205 FKKLAEet-----ktNVKSLSSVVDSMKETCGIT 233 Naegleria gruberi strain NEG-M
EGZ13388     169 QDKLLEav-----cgNARSFDAIVSSIEAQCQAS 197 Phytophthora sojae
AAB68869     322 VLNCTFivfnerrrkDPRIDHFIVSKMCSLMLTS 355 baker's yeast
CCE90640     325 VLNATLvvfterrrkDPRVDHLIFEKMASIMKTP 358 Torulaspora delbrueckii
CCD23469     335 VMNCVFvvfnekrrqDPRIDHRIIERICLLMKAD 368 Naumovozyma dairenensis CBS 421
CCE64655     354 VISCAKivhsekrknDPRIDYRILERMCLAMNTV 387 Tetrapisispora phaffii CBS 4417

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