2E9X,2Q9Q,2Q9Q,2Q9Q,3ANW


Conserved Protein Domain Family
GINS_A
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cd11581: GINS_A 
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Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3
The GINS complex is involved in both initiation and elongation stages of eukaryotic chromosome replication, with GINS being the component that most likely serves as the replicative helicase that unwinds duplex DNA ahead of the moving replication fork. In eukaryotes, GINS is a tetrameric arrangement of four subunits Sld5, Psf1, Psf2 and Psf3. The GINS complex has been found in eukaryotes and archaea, but not in bacteria. The four subunits of the complex are homologous and consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3.
Links
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Statistics
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PSSM-Id: 212547
Aligned: 8 rows
Threshold Bit Score: 62.8977
Created: 22-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2E9X_B     68 VEKLEKMRDHerk--eetFTPmp--spYYMELTKLLLNhasd-----------------------nipkADEIRTLVKDM 120 human
2Q9Q_B     27 IERLEQAWMNekf--apeLLEsk---pEIVECVMEQLEhmeenlrrakr---------edlkvsihqmeMERIRYVLSSY 92  human
2Q9Q_C      3 CEKAMELIRElhrapegqLPAfn---eDGLRQVLEEMKalyeqnqsdvneaksggrsdliptikfrhcsLLRNRRCTVAY 79  human
2Q9Q_D     98 EGWRTVFSADp------nVVDlhkmgpHFYGFGSQLLHfds--------------------------peNADISQSLLQT 145 human
3ANW_A      3 IVKLRELLEAels--stdLNEld---eDFYVEFDSLIKalklsaessrer-------gedveerlylaqLKIAESLMKEI 70  Thermococcus kodak...
EGO59227   76 PASLAEIIHRetkedpeaFSPppp-ppSRALYSQPGTArr---------------------------lnPSYVDDFTQTQ 127 Neurospora tetrasp...
XP_652581   6 HEKLVEAIKEldr--sgnTLPpp---nKELIEQIKEELtgfkesqilnprmv----yanalrqrlkdlyEIYLSERLKRI 76  Entamoeba histolyt...
EHY65094    7 VEYLAMRYLNere--skrLLPyd---eDLMDRVKFLLHrqkkrqreetqr-------nrikehiykieaDRIEWLISEYL 74  Nematocida sp. 1 E...

2E9X_B    121 WDTRIAKLRVSadsfvrqq--eahakldNLTLMEINTSGTFLTQALN 165 human
2Q9Q_B     93 LRCRLMKIEKFfphvlekektrpegepsSLSPEELAFAREFMANTES 139 human
2Q9Q_C     80 LYDRLLRIRALrweygsi---lpnalrfHMAAEEMEWFNNYKRSLAT 123 human
2Q9Q_D    146 FIGRFRRIMDSsqnayne---dtsalvaRLDEMERGLFQTGQKGLND 189 human
3ANW_A     71 IKLRLHKIVDLaveg----------kiaEMTAEEKRLFNVIRAFIER 107 Thermococcus kodakarensis
EGO59227  128 QNSQQDPNSILsppf----------lpsNVAESPAGYLPYHWLEVAE 164 Neurospora tetrasperma FGSC 2508
XP_652581  77 ENIRWEIGTALpvn-----------iraSMTNDEIQYFKQYCKIVGE 112 Entamoeba histolytica HM-1:IMSS
EHY65094   75 LMRLEKIRNNFyie-----------dlsLLSPYEKTYYQEYINLNKE 110 Nematocida sp. 1 ERTm2
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