3R90,3D79,2CX0


Conserved Protein Domain Family
eIF2D_N_like
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cd11580: eIF2D_N_like 
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N-terminal domain of eIF2D, malignant T cell-amplified sequence 1 and related proteins
This N-terminal domain of various proteins co-occurs with a PUA domain. Members of this family are: (1) MCTS-1 (malignant T cell-amplified sequence 1) or MCT-1 (multiple copies T cell malignancies), which may play roles in the regulation of the cell cycle, (2) the eukayotic translation initiation factor 2D, and (3) an uncharacterized archaeal family.
Links
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Statistics
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PSSM-Id: 211421
Aligned: 11 rows
Threshold Bit Score: 53.1264
Created: 1-Feb-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PUA domain
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:PUA domain interface [polypeptide binding site]
Evidence:
  • Comment:Interactions with neighboring (C-terminal) PUA domain
  • Structure:3D79: The N-terminal domain of Pyrococcus horihoshi Ph0734.1 touches the neighboring PUA domain, contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                               ##                                             # #       
3R90_A         9 ENVSNCIQLKtsVIKGIKNQLIEQFpgi-epwLNQIMPK----KDPVKIVRChe---hIEILTVngELLFFRQr-----e 75  human
3D79_A         8 MELKIKHPLSkkDVKEIIAQLSQMFge---eiARKMLNK----KDEVKVAEFdk---tTEIILVndKPMFIRRk------ 71  Pyrococcus hori...
2CX0_A        10 LARLEARALSkkERRSLLERLKPYY-------TRIPFSE----KADLRLVKArtdsgeYEIITVdgVPCLFEWs-----d 73  Aeropyrum pernix
XP_001437994   6 EDLSKPTLLSktGVKELKQSFNDQYpff-keiEDEVFPK----KANIQSFKLrse-ykVEIVQVdkDYICFTKe------ 73  Paramecium tetr...
EGD78578       7 KKKGAKVQVKqsGVRRLRASITEAYprvsqaqLDGLVPV----NGLIKQQKFas---hASAYYYdgLPVFFTVhpk-ggk 78  Salpingoeca sp....
EGR33661       6 EDVSNINPLNktAQKKLREKIIDAFpll-esvLDDFMPK----KCTINSQKFytqehkYELFWVekFPAFFKNdk----e 76  Ichthyophthiriu...
XP_001742861  11 ELKGNRQVVRasDARRLRRELQQQFplladqqLQVVWPVgdgvKTQVELQKLqg---hTSLYFVegLPLFYTDqpknvga 87  Monosiga brevic...
XP_001319356   8 EKLKKHTTLKsnLLTKLKNQAIKEMpli-egiIDEIFPK----KTPVIVYSIeq---hLKLYAVdnKPVMVELg-----t 74  Trichomonas vag...
XP_001579077  25 EKAKNKKTLGsaMISKLREAASATMplf-peiENDYLPK----KAPVTVFGLqd---hAKLYFVgnYPAVVELg-----h 91  Trichomonas vag...
ZP_09707692    1 MEIKRRYYLKkkELKQIREELGKFFa-----dIDDIIPK----KANVEIAITd----kYDMILVddEPVAVRLd------ 61  Methanotorris f...
Q58827         1 MEIRKRYFLSkkDVKKIKKELEVFFe-----nVDEIIPK----KGNVEIAITdd---fEIILVDk-EPIAFKKd------ 61  Methanocaldococ...

Feature 1         ####
3R90_A        76 GPFYP 80  human
3D79_A        72 DLIFP 76  Pyrococcus horikoshii
2CX0_A        74 GRIYP 78  Aeropyrum pernix
XP_001437994  74 DLVIP 78  Paramecium tetraurelia strain d4-2
EGD78578      79 EELLP 83  Salpingoeca sp. ATCC50818
EGR33661      77 DELFP 81  Ichthyophthirius multifiliis
XP_001742861  88 PRFWP 92  Monosiga brevicollis MX1
XP_001319356  75 GDVFP 79  Trichomonas vaginalis G3
XP_001579077  92 GEVFP 96  Trichomonas vaginalis G3
ZP_09707692   62 NKLYP 66  Methanotorris formicicus Mc-S-70
Q58827        62 DKVIP 66  Methanocaldococcus jannaschii DSM 2661

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