Conserved Protein Domain Family
GH71
?
cd11577: GH71 
Glycoside hydrolase family 71
This family of glycoside hydrolases 71 (following the CAZY nomenclature) function as alpha-1,3-glucanases (mutanases, EC 3.2.1.59). They appear to have an endo-hydrolytic mode of enzymatic activity and bacterial members are investigated as candidates for the development of dental caries treatments.The member from fission yeast, endo-alpha-1,3-glucanase Agn1p, plays a vital role in daughter cell separation, while Agn2p has been associated with endolysis of the ascus wall.
Links
?
Statistics
?
PSSM-Id: 211418
Aligned: 88 rows
Threshold Bit Score: 148.582
Created: 7-Feb-2012
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Feature 1: putative catalytic site [active site], 2 residue positions
Conserved feature residue pattern:D EClick to see conserved feature residue pattern help
Evidence:
  • Comment:by similarity to other members of this family
  • Comment:The mechanism may involve one or both carboxylic acid side chains and imply a glycosyl-enzyme intermediate or a 1,2-anhydro sugar intermediate
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
GAA88202      54 RSGPQTVFAHFIVGNaa-------------------------------------------------aMTAEQWESDIREA 84   Aspergillus ka...
EFA78284      41 LNSPKKVFAHYFSLFpisidnkvstddyytnnflkptgeg--gkhlqyggfirerplprpvrpdmstYRDLDMQLEVTRA 118  Polysphondyliu...
ZP_03724527   26 VAEQPMVWAHYTPWHtplnssisays------------------------------yynypifhstgFEKNDYAAEFQQA 75   Opitutaceae ba...
XP_002680766  51 LNSNKFVLAHYFKPFplsidnknpsqdyysvnylqpsgegnkfikqggflrvrplpifapqnasniyWKLTNMEKEVRMA 130  Naegleria grub...
ZP_06241606   28 TAGRSMVWAHNTPWFrpedyplytqgfy---------------------------nfplqpapetghKMEDSLAEEVKIA 80   Victivallis va...
YP_003339463 238 RSFDKKVFAFYFPPFpvsidnkdpskdqhaswldpmgsn----gmyagqgghsrdrplprpvrpeknWRQLDFEVEVRQA 313  Streptosporang...
YP_002360796  58 LGSSKVVFAHYVNSPlqtrqddywpnstcmyyiipgnt-------pgsggnqrvcpgpqitggskstYIIDNLKAEIVRM 130  Methylocella s...
ZP_06244881   55 QPGRKMVFAHTVPWHnlynsqlrvdg-------------------------------yhevalkpdaTLIESAKREIAMA 103  Victivallis va...
ZP_03727932   29 VADQTLAWAHYTPWCtplnttltipn------------------------------yynyplfrstgDNQADWAKEYRQA 78   Opitutaceae ba...
ZP_03726794  201 GKAARKVIVHVVPWYqpnnskkiad---------------------------------aidpqlshlILAADEPDEVRRI 247  Opitutaceae ba...

Feature 1                                                                                        
GAA88202      85 QKAH-------IDGFALNIAPQDs------------------yTDDVLDKAYSAAesv---gnFSLFLSFDYGsg----- 131  Aspergillus ka...
EFA78284     119 LSLG-------LDGFTYDMLSSDet----------------sdHWKRLILLMKNApiv--dsrFKIVLMPDMLagw--sn 171  Polysphondyliu...
ZP_03724527   76 KSQG-------IDGFLVDVVFQKkgr---------------paFDDFVRKMLQAAeg----sgFQIGLCLDVKtt----- 124  Opitutaceae ba...
XP_002680766 131 IARG-------INGWSYDILSVKdigngt---------cfykgTLCELSIMLQAVknvdsqsrFKVVLMPDMSss----l 190  Naegleria grub...
ZP_06241606   81 LNHG-------VDGFFLDFGGDPgkg--------------pahWSHLLPFYLKAAeg----mpFQVGICMDTKis----- 130  Victivallis va...
YP_003339463 314 IAMG-------LDGFIYEHHTSAsd-----------------qRFNQFPAMLAAAkav--dpnFKIMLSPDFPta----- 362  Streptosporang...
YP_002360796 131 IARG-------INGVAVNLFSLCdwsesgancpgnpggggmsgYPGTLINMLNAAaav--drrFKVLPMPDMSag----i 197  Methylocella s...
ZP_06244881  104 QAVG-------IDGFFMDIGTAD--------------------QMSFADCYLEAAkg----tsFLVGFCFDIPpldgeag 152  Victivallis va...
ZP_03727932   79 KAQG-------IDGFFVDLVFSKnqq--------------kaiYSDTLHAMLKAAeg----sdFLIAPCLDVKtt----- 128  Opitutaceae ba...
ZP_03726794  248 EAHLlamrkagIDIVALDAQVRTgwkrgdnpk---mvlwhnrqVDAFLEAMKNVAp------dMRFCLQLDRGggap-gs 317  Opitutaceae ba...

Feature 1                                                                                        
GAA88202     132 gPWPADRVISTINTYRNRSa---QYHy---qGKPLVSTFIGa---------dNAGDWSYIKGS-----ADCFFMPSWPDm 191  Aspergillus ka...
EFA78284     172 tANIADTFVPIIKKLWDSPyngtLLRds--tGKLVLSPYRAds--------kTGAWWQNQITKfnqvgIQISFWPVFPDi 241  Polysphondyliu...
ZP_03724527  125 vETQVRELSRMLSDYGAHP----NYPrh--nDRPIVATYTWgk--------wTPQDWADIRAGlqsagHNIHLIANVDPn 190  Opitutaceae ba...
XP_002680766 191 sLSDIVTIVKYLYNDTAIY----RNG-----SKPVIAPFYAeg--------vSPIQWQSLLQNltsdgFPILLLPTFLTi 253  Naegleria grub...
ZP_06241606  131 kDYWVRELKRLLKANGDHPny-pRYN-----GKYVVCAYQFlqwenqqpggwTIEEWKQLRAElkeagIELYIVANAAPl 204  Victivallis va...
YP_003339463 363 kDSPHDKVIADILMAKGHPs---LYKld--dGTIPLAPFYPer--------hPAAWWDQLRDKlaaqgMKTSLFPIFLSw 429  Streptosporang...
YP_002360796 198 kPSDLPNLWKAKIGGTTIYnhpnLYRwpdanNYPELSPFCTecfp----asqYSAAFATMKANg----TPISWAPTFGS- 268  Methylocella s...
ZP_06244881  153 iQLSVDSTEKIVKNLGNHP----NFPki--gNKYIFFSFSGaw-------rhSPEKIAEIKRRlkakgIEIYYVLHRETa 219  Victivallis va...
ZP_03727932  129 vEKQVAELDRMLTLFGHHPny-pRYN-----NKPIVVTYTWsq--------wTPDEWQAIRTQlhdkgHDIYLVAHLARs 194  Opitutaceae ba...
ZP_03726794  318 vEVWSPALKALEENYTRHPn---YYHi---gGRPVLLSFFLne-------kmPDALLREIRKQs---nTNFYFVGSIVEn 381  Opitutaceae ba...

Feature 1                                                                                        
GAA88202     192 --------gPARLRDyl-----------diIDGAFSWDAWPVGa--------------------qNKNVTSDREWMHa-- 230  Aspergillus ka...
EFA78284     242 --------nQNYLNNyg-----------siSVGQSEWDGNCVSt---------------------APGFVTASNFLHn-- 279  Polysphondyliu...
ZP_03724527  191 ya----qlkRDWLDSya-----------phFDTAYSFGLAGINg--------------------mPRQQMADLIADAah- 234  Opitutaceae ba...
XP_002680766 254 --------sSKYINVemy---------aniSIGMGVWATVGVPt--------------------qGSSSIAYASTVRnak 296  Naegleria grub...
ZP_06241606  205 p------neKLDLDRltra--------ldaYDCVFLFDAPGHAd---------------------ETPEVNNEKLADfc- 248  Victivallis va...
YP_003339463 430 ng-----tgKTEWNDh--------------VVGYSSWGSKWVS----------------------TTESLRKGGIEAh-- 466  Streptosporang...
YP_002360796 269 ---------LGCNGQv--------------NGCVFSPYASLPTvsingiqgvsadrtmaalalrnVGGASGGKTYGGgtp 325  Methylocella s...
ZP_06244881  220 e-------wRSNVEKmvegtyidpygevcdSFYPFMFSSRAWNdrgep-------------egvhRKEFVALRNALAr-- 277  Victivallis va...
ZP_03727932  195 yq----mqtREWLLTql-----------anADAAYAFGFRGLD----------------------GMPRDYTASLIStva 237  Opitutaceae ba...
ZP_03726794  382 pgkllgpltRAVINSrrm----------deAIDIFDGIDICPL----------------------GAHRDWLEASGHt-- 427  Opitutaceae ba...

Feature 1                                                                      #  #              
GAA88202     231 ---lSGKPYMMPVSPWFYTNLp---qWNKNWLWRGDDLWHIRWEQVMNL--QPAFVQIISWNDYGESHYIGPIYEpg--- 299  Aspergillus ka...
EFA78284     280 ----NGKKYMSPVMSQNHRPK-----SYKFWEANNSGAIRAMWNSAIVS--GAEWIQIITWNDYSEGTELSPSTGtqf-- 346  Polysphondyliu...
ZP_03724527  235 ---aHGKTYMATLYPGYYGAWln-grNDFYQPHRGFDQLHDTYLAIRQK--RDHWLHFTTWNDHDETSVLPMLFTpa--- 305  Opitutaceae ba...
XP_002680766 297 --snNSLLFWLGMMPQTYKPK-----DCILYDSYNSLAYRNAWMSTLQT--NADIVHVATWNDFSESGQLQPITDlqntt 367  Naegleria grub...
ZP_06241606  249 --rkNGKRFMACLHPGYYGAWlw-gfNDFYNPFRGFDMFYRMFASARKH--KAHWTHLTTWNDLVETAVLPRVFTfg--- 320  Victivallis va...
YP_003339463 467 ---kRGRLYMAPASLEDVRPR-----DKRLWEPANSQLLQQSFLKAAQG--DADIIALITWNDYAESWVAPSVKRgya-- 534  Streptosporang...
YP_002360796 326 inwtGPVKLFGGMSPQGYQSG-----GGTVYEAQNSAAYRGAWESQIALgaSLGNIMIFTWNDFGESTAVEPSSNqfgap 400  Methylocella s...
ZP_06244881  278 ----FNKKPVATITPGYRGNWledlgHYGYVPFRGYDKIWDCFHAFKPD--EVDWLNIATWNDIGETPIFPRTFDfga-- 349  Victivallis va...
ZP_03727932  238 --deAGKPYMPGLVHGYYGAWln-grNDFYQPHQGFDQLHKSFQLVRQG--RDRWLHFTTWNDHDESSLLPMLFTta--- 309  Opitutaceae ba...
ZP_03726794  428 ----LVPRLRSTGKPLFWGVGtgyyrRGVAFIEPAYNYLHSLWMFALRE--NADHVIVWTWNDFAEDHDIFPSTLkgn-- 499  Opitutaceae ba...

Feature 1                                          
GAA88202     300 ---mpDGSSKYVLDCPHDAWRALLPHYIAAYRGS 330  Aspergillus kawachii IFO 4308
EFA78284     347 --syyDISAYYLRWYKLGQAPVINRDALYYFHRN 378  Polysphondylium pallidum PN500
ZP_03724527  306 ---npRITKAYSDAFKNIPPTSTKPEICLAYHRE 336  Opitutaceae bacterium TAV2
XP_002680766 368 gngfyDLTAYYAHWWRTGLQPTIIRDVVYYFYRK 401  Naegleria gruberi strain NEG-M
ZP_06241606  321 ---laHTLTSYSSYLKNSPQPSETPDVLAAYLRE 351  Victivallis vadensis ATCC BAA-548
YP_003339463 535 ---psDLIAYYTTLFKTGKAPAVARDALYYFHRS 565  Streptosporangium roseum DSM 43021
YP_002360796 401 stgyyDLTGYYTTWWRKGAAPQITNDAIMYFYRR 434  Methylocella silvestris BL2
ZP_06244881  350 --saeVMEAFIDQYFRQNPAPKQSEPRVYFAANR 381  Victivallis vadensis ATCC BAA-548
ZP_03727932  310 ---tpLLTKAYADAFKGIPPSTPQPEVCFAYHRE 340  Opitutaceae bacterium TAV2
ZP_03726794  500 --avlDLMALYIEWYKRGQFPKLTKDRIFVSWPL 531  Opitutaceae bacterium TAV2

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap