2XZM,2IF1,2OGH


Conserved Protein Domain Family
eIF1_SUI1
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cd11566: eIF1_SUI1 
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Eukaryotic initiation factor 1
eIF1/SUI1 (eukaryotic initiation factor 1) plays an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown.
Links
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Statistics
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PSSM-Id: 211318
Aligned: 48 rows
Threshold Bit Score: 88.7459
Created: 30-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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rRNA bindingMutations
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:rRNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2xzm: Tetrahymena thermophila eIF1 binds 18S rRNA in the 40S ribosomal subunit, contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #  ## #                #  ### ### #                #  #                
2XZM_F        17 THIHIRVEQRRgRKCFTTVEGIPpEFDYEKIMKYWKKWLSCNATIVEede---gkKVIKLNGDHRNQIQQFLSEEGia-- 91  Tetrahymena the...
XP_650999     26 FIVHFRIQQRNgRKCVTTITGIPeRYDADLILKHFKRTFNCNGSLQKskd---geVEFKLSGDQRKAASNFFLAEGil-- 100 Entamoeba histo...
XP_001442996  20 FVIHIHLKKRSaRKTQTIIVGIPdEFDLNKIIRFWKKQFNCTGGIISkdedygdqVTIRLTGDNRQQIAKFLVEEGia-- 97  Paramecium tetr...
XP_001590408  80 GRPKRNMEGKKkPHMLTTVQGLPdRFNMKKVVKAFKKKFACACSIVEdkv---fgEVIQIQGDYRQKIYEFLTTKDglel 156 Sclerotinia scl...
XP_002134351  22 KQVHIRIQKGFgYKMQTTVQGLSdEYKLMKIVRAFKKEFTCNVIVTEhpe---ygEVIQVQGDQRQRISRWLVRMGla-- 96  Drosophila pseu...
XP_002671504  23 SKIHVRIFSRSnNKKITTIEGLSqNIPLKTLTKTLSSLFECSAIVVDdee---rgKIITLQGDQRMNVVQYMLRENiv-- 97  Naegleria grube...
XP_002680076  30 NFVHIRVQKRNgRKCVTIVEGLPrNFKFKKFISGVKHKFCCNGTIVEdek---agKVIQVSGDQRGNISEFLLEEGiv-- 104 Naegleria grube...
CCC53123      24 QKVHIRVQQRKgKKFVTSVQGLNqDLNFRRINREFQRRWGCNGTVIStsd---agKVIQLQGDWSHHIRKFLLDEHma-- 98  Trypanosoma viv...
CCD34173      78 GRAKFGRDGKRkQHWVTTIEGLPeKFEKKKIVQHFKKTLACAGSIVKnet---wgEVIQVQGDYREAVFQFLTGKTglel 154 Botryotinia fuc...
EGZ30559      25 GKVHVRVQQRNgRKCLTTVQGLAdDLDVKRILKAFKKNFSCNGAIVKdde---lgEIIQLSGDQRTNIREFLLDQEic-- 99  Phytophthora sojae

Feature 1                 
2XZM_F        92 aVDNITIHG 100 Tetrahymena thermophila
XP_650999    101 lPENIKIHG 109 Entamoeba histolytica HM-1:IMSS
XP_001442996  98 lQDNIKVHG 106 Paramecium tetraurelia strain d4-2
XP_001590408 157 dEENVVVHG 165 Sclerotinia sclerotiorum 1980 UF-70
XP_002134351  97 kSDQVKLHS 105 Drosophila pseudoobscura pseudoobscura
XP_002671504  98 rRDQIVCPG 106 Naegleria gruberi strain NEG-M
XP_002680076 105 tKESLKVHG 113 Naegleria gruberi strain NEG-M
CCC53123      99 tEQNLEIHS 107 Trypanosoma vivax Y486
CCD34173     155 sENVVVVHG 163 Botryotinia fuckeliana
EGZ30559     100 sDSQVVLHG 108 Phytophthora sojae

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