1UG3


Conserved Protein Domain Family
W2_eIF4G1_like
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cd11559: W2_eIF4G1_like 
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C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
Links
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Statistics
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PSSM-Id: 211397
Aligned: 52 rows
Threshold Bit Score: 86.1846
Created: 8-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1UG3_A        206 LPSEELNRQLEKLLKEGs--sNQRVFDWIEANLSEQQIVSn--TLVRALMTAVCYSaiif--etplRVDVAVLKARAKLL 279  human
XP_312438    2101 LLECKVASSIREFLRNDa--pNETIFQWISSHVSEQQENSs--EFIRTLTTVVLEHcin-----ktKLDTAKIEKWHMLL 2171 Anopheles gam...
EFR21557      771 VDMPAVAARLHQFLQSDa--kNVEIFSWIDKYVGSERQQSn--EFIRTITRVIFKNcmd-----erRLNFVKFERWHQLL 841  Anopheles dar...
XP_001853216  817 LDMQTVGTQIKQFLKSGa--kFVEIFGWVAEYVGPERVTSd--EFIRTLTKAVIEHcid----nktKLNVQEITKWHQIL 888  southern hous...
EFA03765     1465 LTYEQMHNKLREFYTKKm--sFDEIVNWITANAGDRVKDS---KFVRMLATSIFDFaiv-----rqRLVIENLKANYKLL 1534 red flour beetle
EFN71944     1795 LSFEQIQENLTRLMKENs--sFDEICSWITANVGNRDKDP---KFIRHLMTAILETtlerh-ygtwKLNVDSFTSLQTLI 1868 Camponotus fl...
XP_002163155   13 SHSNNVLKGLLRILQEKg--dNNKITSYIDSECSNCKSDP---YFIKDLTSMICKStlvkdatntcSCNKDELEKRINIL 87   green hydra
EFX67152     1433 QVNIDFQHSLEKYLRDAtqltTDDVCSWIQKQYVGEVNPAfirALVTAVTESSIEGrgt-----dsKLNNTVLKNRTEVL 1507 common water ...
NP_524640    1511 KHVKNVIDHIEHLLKEGt--tADCIIDYSNGNIMVVDKLFi-rGLTETLSNFSIHYkdn----sykLESETFQKFCIPVL 1583 fruit fly
BAH72628      105 FLLSIAMYDKMKMTHSKp--lYDVLHSWISTNINAEIIKCp--QFVRALTIAIVIVcsk----pnhSYEDFFDHVHVKLL 176  pea aphid

1UG3_A        280 QKYLc--------DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 338  human
XP_312438    2172 QRYIq-------gKAERELQALYAVQLLVERMQHPQHLLQTIFQQLHEFEVVMEGFHLWKEERSDHE 2231 Anopheles gambiae str. PEST
EFR21557      842 QKYVh-------qQPERELQALYAVQQLVVELQHPQNLLSSIFQQLYDRYIVMEGFVLWKESQDPLE 901  Anopheles darlingi
XP_001853216  889 QKYId-------sKPERELQAMYAIQRLVVELEHPQNLLHTILEQLYDNDVIMEGFSLWKDSQDPLE 948  southern house mosquito
EFA03765     1535 QKYVd-------nNSDYELQCLYALQALIQKLEHPKGLLLTICNQLYEDAIISQDSFIAWEASTDPA 1594 red flour beetle
EFN71944     1869 QRYAd-------aNEKLELQCLYAIQRYINKIEFPPGTLVPIMNRLWMDNVISSDAFLTWQKEIPEG 1928 Camponotus floridanus
XP_002163155   88 LKYId-------gNKNLELFALYGIQQLVTTLHHPKGLAIDLFQELYNRDIISEETFFTWESSKEFP 147  green hydra
EFX67152     1508 RRYVd-------nIADRELQLLYAVQTLVTQRQHPKGLIQGIFETLYDSNVVSEEGFESWVSADDPL 1567 common water flea
NP_524640    1584 QRYId-------sNEDHQLECLYTLQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKDQS 1643 fruit fly
BAH72628      177 TCYIrseplpepeIQAREVQCLYGIQIMSAALEHPGGMVLRLFHKLYQDSVISKESFELWKKEDEFK 243  pea aphid
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