Conserved Protein Domain Family
NTP-PPase_His4
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cd11546: NTP-PPase_His4 
Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in His4-like fungal histidine biosynthesis trifunctional proteins and their homologs
This family includes fungal histidine biosynthesis trifunctional proteins and their homologs from eukaryotes and bacteria. Some family members contain three domains responsible for phosphoribosyl-AMP cyclohydrolase (PRAMP-CH), phosphoribosyl-ATP pyrophosphohydrolase (PRATP-PH), and histidinol dehydrogenase (Histidinol-DH) activity, respectively. Some others do not have Histidinol-DH domain, but have an additional N-terminal TIM phosphate binding domain. This family corresponds to the domain for PRATP-PH activity, which shows significant sequence similarity to Mycobacterium tuberculosis PRATP-PH that catalyzes the second step in the histidine-biosynthetic pathway, irreversibly hydrolyzing phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate.
Links
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Statistics
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PSSM-Id: 212153
Aligned: 17 rows
Threshold Bit Score: 100.82
Created: 1-Sep-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
metal binding
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E E DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on sequence similarity to other superfamily members.
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                              #  #            #  #                      
P00815       244 GLVGLESLLKQRLqdapeESYTRRLFNDsaLLDAKIKEEAEELTEAKGKKELSWEAADLFYFALAKLVANDVSLKDVENN 323 Saccharomyces c...
CCA22236     336 GLRSLEKMLQSRVenaptGSYTKRLLEDteLLRDKLVEEAQELAEAESKEEVAGEAADLLYFLMVKCVAAGISLTDIEKQ 415 Albugo laibachi...
EGD73441     296 GLTALQETLRSRLetapeGSYTRRLFNDpaLLQKKVVEEAIELTEAKDTDHIASEMADLLYFSLALCTKAGVSLDDVERK 375 Salpingoeca sp....
EGG04025     303 GFSHLESVLLNRFqnstpGSYTNRLFNDekLLRAKIMEEAEELCEAESHEDVKNEMADLFYFALCRCISKGVSLKDVEDV 382 Melampsora lari...
XP_001749629 208 GIALLESVLEDRKtnapkGSYSQRLYNDpgLLKNKLVEEAIELSEADTADHVASEAADLVYFAMVKCVSAGVSFTDVERV 287 Monosiga brevic...
XP_002287285 162 GLRHLEGTLQQRLkdapvGSYTKRLFEDeiLLRDKLVEEAQELSEADTKQHVAEELADVLYFAMVRAAKAGVSIDDAVEE 241 Thalassiosira p...
YP_004366642 347 SMERLYGTIAERFanprpGSYTATLNDK--RVREKILEEAEELTEAEGKDEVIWEAADLLYFASVLMYKEGVTWQDVYNE 424 Treponema succi...
YP_004699053 339 TWELLQNIVTERFrnpkpGSYTATLDDE--RVREKVMEEAEEVCTAKTHDEIIWEVADLLYFTTVLMTRAGVSVVEVMAE 416 Spirochaeta cal...
NP_986251    245 GLESLEQIVDQRIadarpESYTLRLVGDteLLNSKIKEEADEVIEAITPAELQWEVADLLYFLMVKMRSNNVTLKEVEAN 324 Ashbya gossypii...
YP_003146047 326 DLDVLDRVFEQRMqsqevTSFSQKLLASddLQQEKLREECEELIEADDQDEVRWEAADLIFFALARAKSKGVAASDIINE 405 Kangiella koree...

Feature 1            
P00815       324 LNMK 327 Saccharomyces cerevisiae S288c
CCA22236     416 LDKR 419 Albugo laibachii Nc14
EGD73441     376 LDRR 379 Salpingoeca sp. ATCC50818
EGG04025     383 LNKR 386 Melampsora larici-populina 98AG31
XP_001749629 288 LDRR 291 Monosiga brevicollis MX1
XP_002287285 242 LDRR 245 Thalassiosira pseudonana CCMP1335
YP_004366642 425 LDRR 428 Treponema succinifaciens DSM 2489
YP_004699053 417 LDRR 420 Spirochaeta caldaria DSM 7334
NP_986251    325 LNMK 328 Ashbya gossypii ATCC 10895
YP_003146047 406 LGAR 409 Kangiella koreensis DSM 16069

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