Conserved Protein Domain Family
NTP-PPase_u5
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cd11542: NTP-PPase_u5 
Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea
This family corresponds to a group of uncharacterized hypothetical proteins from bacteria, showing a high sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, members in this family consist of a single MazG-like domain that contains a well conserved divalent ion-binding motif EXX[E/D].
Links
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Statistics
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PSSM-Id: 212149
Aligned: 17 rows
Threshold Bit Score: 84.6828
Created: 1-Sep-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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metal binding
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E E DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on sequence similarity to other superfamily members.
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                    #  #                
YP_003307468   4 INSLQKEIHKNAvshGWWDSkr---------------------------eFGTLIALCHSELSEALEENRKGIpinqtyy 56  Sebaldella term...
ZP_03494834  266 FEAIVDDVHETAvskGWHETkv---------------------------pMPIHLALIHSEVSEALEADRKGYge----- 313 Alicyclobacillu...
NP_348552      3 INELAKEAYSNAkahGFWEDferiqdvideimygktklspssiktfkinaICTRLMLITGEVSEAMEGLRKNDln----- 77  Clostridium ace...
ZP_03724116   28 WTALASEIYAIGkasGFYDHahtd----------------------pefnHAEKLALMHSELSEALEGLRDGPfpgkadd 85  Opitutaceae bac...
ZP_03317732   12 IKQLQQQIHQQNkeaGWWDNpr---------------------------kKGTLLCLIHSEISEAMEGERKNLmdnhl-- 62  Providencia alc...
YP_390927      4 LNEWAQEIHANNvaaGWWEDep---------------------------cIYTKMQLISTEIAEATEGERKNLmddkl-- 54  Thiomicrospira ...
ZP_08529672    6 LNSIAAEIHASNa--HWWRDpange--------------------rldrnKGEMLMLVVSELSEAMEGERKNLmddhl-- 61  Agrobacterium s...
YP_004247843   3 VKQLQDKCFGHAlthGFIRKnm---------------------------dIQKLLDEVHGEVDEALYASVAGKradyqky 55  Spirochaeta sp....
YP_003755324  20 ISAAMGLAHTTAenaGWYRNpetge--------------------pvkrnFGEVVALMHSELSEALEADRKNLmddkl-- 77  Hyphomicrobium ...
CBZ04158      11 IKEMVNDAHRNAidhGFWEEeqniitkmcvkef-----edeeikavkrafMCQRLMLIVSEVSEAVNALRKDDke----- 80  Clostridium bot...

Feature 1                            #  #                                                        
YP_003307468  57 t---------esgkmegVPSELADTVIRIMDICEYYGi------------------------------------------ 85  Sebaldella term...
ZP_03494834  314 ---------------dkVAEELADVIIRVMDTAAAHGl------------------------------------------ 336 Alicyclobacillu...
NP_348552     78 ----------------nFKEELADVAIRLGDLCGGLGi------------------------------------------ 99  Clostridium ace...
ZP_03724116   86 ----------kptyrpmVEVELADTIIRIMNYATHCGl------------------------------------------ 113 Opitutaceae bac...
ZP_03317732   63 ------------phrkmAEVELADAVIRILDYAEAFGy------------------------------------------ 88  Providencia alc...
YP_390927     55 ------------ahrkmGEVELADALIRTLDLGAHLNltyksfftpyilddkpiaakhfqlngylielgfrihnhideyi 122 Thiomicrospira ...
ZP_08529672   62 ------------phrkmAEVELADAKIRLFDFAGGCGfklvdpeglaidlsdnraealfaivrlvtgvg---nliesnwh 126 Agrobacterium s...
YP_004247843  56 cevgkgneafikyvkdsLEDELADTVMRVATICGYLGi------------------------------------------ 93  Spirochaeta sp....
YP_003755324  78 ------------phrsgIEVEFADCIIRIFDTAQALGl------------------------------------------ 103 Hyphomicrobium ...
CBZ04158      81 ----------------nYAEELADIILRTSDTSLGDTv------------------------------------------ 102 Clostridium bot...

Feature 1                                                 
YP_003307468  86 -----------------------DLEKVILEKHEYNKNREF 103 Sebaldella termitidis ATCC 33386
ZP_03494834  337 -----------------------DLAGALFRKMAINKAREY 354 Alicyclobacillus acidocaldarius LAA1
NP_348552    100 -----------------------DLEEEIKKKMEINKDRPY 117 Clostridium acetobutylicum ATCC 824
ZP_03724116  114 -----------------------NVAGALVEKAAFNATRGH 131 Opitutaceae bacterium TAV2
ZP_03317732   89 -----------------------DIESAINEKLEYNKYRAD 106 Providencia alcalifaciens DSM 30120
YP_390927    123 syvsriysvlinaliivseskgyDIESAMIEKLEFNKTRQD 163 Thiomicrospira crunogena XCL-2
ZP_08529672  127 vrvgieitrvlatidayaakfgyDVDGAVTEKREYNAVRAD 167 Agrobacterium sp. ATCC 31749
YP_004247843  94 -----------------------DLQKHIAEKIAFNRSRGY 111 Spirochaeta sp. Buddy
YP_003755324 104 -----------------------DLPGAIIEKNRFNQQRAD 121 Hyphomicrobium denitrificans ATCC 51888
CBZ04158     103 -----------------------DIEKEIKKKMKKNRSRPY 120 Clostridium botulinum H04402 065

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