Conserved Protein Domain Family
NTP-PPase_u1
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cd11538: NTP-PPase_u1 
Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria
This family corresponds to a group of uncharacterized hypothetical proteins from bacteria, showing a high sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, members in this family consist of a single MazG-like domain that contains a well conserved divalent ion-binding motif EXX[E/D].
Links
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Statistics
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PSSM-Id: 212145
Aligned: 15 rows
Threshold Bit Score: 118.961
Created: 29-Aug-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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metal binding
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E E DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on sequence similarity to other superfamily members.
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                          #  #                            #  #          
NP_353786      2 FADMMPRFEEASQKYAAENGIfRDPDWYMLKLQEEVGEVTQAWNRLTGRGRikgrskeemKRDLADETADLLGHVLLLAH 81  Agrobacterium t...
YP_004571025   3 LANLSEDLTAVSTHYADRYNIdQSDDWLMLKLQEELGELTPAYLALTGRTRdrgrsaseaRSQFEDELTDVIGHALLIAQ 82  Microlunatus ph...
YP_004541379   3 LKDLADELEIISRVYERRFGVeRTDDWLVLKLHEEVGELTQAYLAASGRSRdrgeepgeaDTAFRAELADVLAQLLLVAR 82  Isoptericola va...
ZP_06971523    3 LEQLSAAVEGVSQTYAERFNIeRDTTWFVLKLQEEVGELTQAYLMLSGQARtkgkspeeiQADFRKELADVFCQTLLLAR 82  Ktedonobacter r...
ZP_07705772    3 LNEWSGRIEGISAAYGEYFAVeRTPEWVLLELTEEVGELTQAYLASSGQGRnrgksddelRQDLEGEVADAFAMILVFAR 82  Dermacoccus sp....
AEQ51966      12 LAALTRAVGQVSDTYATRCDIdRDRDWAALKLSEETGELVAAFLKTTGRGRragesedglRQALEDEAADVLAMLLIFAK 91  Pelagibacterium...
ZP_02166078    5 LHEIQQEVEAVSRIYAKNCNVrRDDDWYFLKMQEETGELLQAWLRLTGRGRqkgdpeaqiRQQLEDELADCMAQVFLIAE 84  Hoeflea phototr...
YP_003380525   3 ITELTERAEKISVKYGESLGIeRDGDWFLLKLQEEVGELTQAYLQVTGRARpknrtehelRDGFELEFADVLCQLLLLAR 82  Kribbella flavi...
ZP_08263358   13 LEAFVDRLKAISDRYQRVYDVdRSGDWHLIKVQEEMGELTQAYLAMTGRSRrsv---dgaRHDVAMEMADVICMVLLMAR 89  Asticcacaulis b...
ZP_05741681    4 LTQLTSAAKQVSDLYARRFGVtRDAAWYLGKMTEELGEVTSAYLSLAGQTRkd-----gsKSDLENEVADLLGFLLLFAD 78  Silicibacter sp...

Feature 1                         
NP_353786     82 YNGLDIEGAIERKWRFA 98  Agrobacterium tumefaciens str. C58
YP_004571025  83 RFEVDLDVAFSRKWLAY 99  Microlunatus phosphovorus NM-1
YP_004541379  83 RFDVDLEAEVERKWFRW 99  Isoptericola variabilis 225
ZP_06971523   83 HYDIDLEHEIEEKWLRW 99  Ktedonobacter racemifer DSM 44963
ZP_07705772   83 SAGIDIESALTTKWLPW 99  Dermacoccus sp. Ellin185
AEQ51966      92 QNGIDLTAALERKWFRY 108 Pelagibacterium halotolerans B2
ZP_02166078   85 RFDIDVEKAIGRKWFKY 101 Hoeflea phototrophica DFL-43
YP_003380525  83 HHGVDVPAAVERKWLIR 99  Kribbella flavida DSM 17836
ZP_08263358   90 SEGIDLNAAITEKWLKW 106 Asticcacaulis biprosthecum C19
ZP_05741681   79 WQGIDAGAAFERKWGAY 95  Silicibacter sp. TrichCH4B

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